Evolving insights into the role of local shear stress in late stent failure from neoatherosclerosis formation and plaque destabilization

The process of neoatherosclerosis formation in stented portions of the coronary arteries is central to an understanding of the natural history of stent outcomes, both in the short- and long-term. Early studies demonstrated that the short-term tissue response to stent implantation was related in part to the local hemodynamic microenvironment, i.e., endothelial shear stress (ESS), such that low ESS led to increased neointimal thickness in bare-metal stents (BMS) compared to first generation drug eluting stents (DES), within which the anti-proliferative agent suppressed the neointimal hyperplasia response.

Source: International Journal of Cardiology - August 10, 2018 Category: Cardiology Authors: Peter H. Stone, Ahmet Umit Coskun, Kevin J. Croce Tags: Editorial Source Type: research