Role of L-selectin on leukocytes in the binding of sialic acids on sperm surface during the phagocytosis of sperm in female reproductive tract

In either natural fertilization or artificial insemination, hundreds of millions of sperm are ejaculated or inseminated and then deposited in the female reproductive tract, but only a few sperm reach the ampulla or the site of fertilization. This dramatic reduction in numbers clearly highlights the obstacles that sperm must overcome in order to reach the destination for egg fertilizing. Phagocytosis of sperm by leukocytes are repeatedly observed and generallyconsidered to be one of the most important barriers, but the mechanism of the phagocytosis of sperm remains unclear.
Source: Medical Hypotheses - Category: Biomedical Science Authors: Source Type: research