Women With Asthma More Likely to Develop COPD
More than 4 in 10 women with asthma developed chronic obstructive pulmonary disease (COPD), and heavy smoking and obesity were among the significant risk factors, a new study found.
Aim: Clarify the cause-effect relationship between COPD and type 2 diabetes mellitus (DM2) and assess the prevalence of latent carbohydrate metabolism disorders in COPD patients.Material and methods: In a multicentral study, a retrospective cohort analysis of the reciprocal reported prevalence of COPD (300) and diabetes mellitus type 2 (DM2) (400 patients) was performed, and an oral glucose tolerance test (OGTT) was performed in 40 patients with COPD without obesity with normal indicators of sugar in the blood on an empty stomach. As a control, population indices were used, and in the estimation of OGTT in COPD patients, t...
Background: Phenotypic differences between early-onset (EODA) and adult-onset (AODA) difficult asthma in adulthood are not well described.Aim: To characterise EODA and AODA in difficult asthma.Methods: The Wessex AsThma CoHort of difficult asthma (WATCH) is a longitudinal study at University Hospital Southampton (UHS) UK set up in 2015. To date, 380 patients are enrolled from the UHS tertiary difficult asthma clinic. Clinical features of EODA (age ≤18 yrs) and AODA (age>18 yrs) are presented here.Results: Of 368 patients with available data, 51.6% had EODA and 48.4% AODA (median age of onset 4.0 yrs v 40.5 yrs respectively (p
Background: Multiple co-morbidities are associated with disease control, healthcare utilization and quality of life in difficult asthma.Aim: To evaluate the prevalence of comorbidities in patients with difficult asthma in the Wessex AsThma CoHort of difficult asthma (WATCH).Methods: Our prospective observation cohort study has enrolled 380 patients with severe asthma. History of co-morbidities is collected at enrolment. Data is presented as percentages and chi squared tests were used to calculate differences between groups.Results: Comorbidity(n)Prevalence (%)Gender Difference(male % vs female %)Age of Onset Difference (ea...
Conclusion: The 112 algorithm is useful for prediction of obstructive lung function, but the sensitivity to predict peri-operative complications is low. The added prognostic value of VC and IC should be further investigated.
Conclusion: CPET is the gold standard test for evaluation of exercise intolerance. The analysis of flow–volume loop may seem useful to identify ventilatory constraint, but its clinical utility requires further study.
Introduction: OSA is recognized to be a heterogeneous disorder and worsens both COPD and Asthma. So it may be useful to understand the clinically important phenotypes of OSA in asthma and COPD.Aims and Objective: The study aimed to know that wether OSA affects sleep stages, underlying inflammation and clinical profile of these two groups of patients differently.Method: A total of Sixty (30 each) diagnosed patients of moderate to severe asthma and COPD presenting to Vallabhbbhai Patel Chest Institute underwent Type 1 diagnostic polysomnography (PSG), inflammatory marker (IL4, IL5, IL6, IL13, hSCRP and FeNO) testing. The sym...
Background: Airflow limitation may be found in patients with both asthma and COPD and is possibly associated with more symptoms and worse outcome. We aimed to identify factors associated with airflow limitation in a well-characterized, population-based sample of adults.Methods: From the Danish Health2006 cohort (n=3,471) we selected participants aged 35 years and older at enrolment (n=2,959). We defined airflow limitation as FEV1/FVC
Conclusions: Our findings provide first evidence for the use of drug administrative databases to identify ACO in old women with asthma. Active smoking, late onset asthma, and obesity increased the risk of progression towards ACO.
Introduction: Airway eosinophilic inflammation can be found in asthmatic and COPD patients. Blood eosinophil count is deemed good surrogate marker of sputum eosinophilic inflammation; however, controversial data have been published both in asthmatic and COPD populations.Methods: Sputum was induced in stable patients with asthma or COPD with hypertonic saline solution. Blood eosinophils were measured. Frequency of comorbidities was recorded.Results: Sputum and blood eosinophils were correlated both in asthma and in COPD. EosinophilsAll (n=93), rho; PAsthma (n=52), rho; PCOPD (n=41), rho; PBlood % VS sputum %0.67;
Conclusion: Enose technology is able to classify newly presented patients with a differential diagnosis of asthma or COPD with high accuracy into their classic diagnostic labels and clinical/inflammatory phenotypes. These data validate breathomics for stratification of patients with chronic airway diseases in the doctor’s office.