Seven new resin glycosides from the seeds of Quamoclit  ×  multifida

AbstractSeven new resin glycosides, multifidins III (1) –IX (7), were isolated from the seeds ofQuamoclit × multifida (syn.Q. sloteri House) (Convolvulaceae), along with five known glycosides, quamoclinic acid B methyl ester (8), operculin XIII (9), quamoclin I (10), QM-10 (11), and QM-12 (12). Their structures were determined on the basis of spectroscopic data and chemical evidence. These compounds were of two different types, i.e., those with macrolactone structures and those with non-macrolactone structures. Additionally, cytotoxic activity towards HL-60 human leukemia cells of1,2,5,8,9,11, and12 was evaluated. Among them, macrolactone-type resin glycosides (jalapins),1,2, and9, specifically demonstrated clear cytotoxic activity with IC50 values of 3.46, 14.7, and 10.9  μM, respectively.
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research