On the meaning of the word 'epimutation'
On the meaning of the word 'epimutation'
Trends Genet. 2014 Oct 6;
Authors: Oey H, Whitelaw E
Abstract
The word 'epimutation' is often used in a manner that can be misinterpreted. The strict definition of epimutation is a heritable change in gene activity that is not associated with a DNA mutation but rather with gain or loss of DNA methylation or other heritable modifications of chromatin. Unfortunately, there is a growing tendency in the cancer field to use the word in situations in which underlying DNA sequence changes have occurred.
PMID: 25301328 [PubMed - as supplied by publisher]
Source: Trends in Genetics : TIG - Category: Genetics & Stem Cells Authors: Oey H, Whitelaw E Tags: Trends Genet Source Type: research