Daclatasvir Plasma Levels in a Cohort of Patients with Hepatitis C Virus Infection Taking Methadone: A Prospective Analysis

Conclusion: We found a significant difference in DCV levels at 2 weeks and 1 month: 150 ng/mL in patients without MET and 313 ng/mL with MET at 2 weeks (p #x3c; 0.001), 149 and 279  ng/mL at 1 month (p = 0.006). DCV levels were lower in cirrhotic patients (p #x3c; 0.001); among cirrhotic patients we also evidenced higher DCV concentrations in patients receiving MET at 2 weeks, 1 and 2 months (p #x3c; 0.001,p = 0.005, andp = 0.031, respectively). In multivariate analysis, the only predictive factor associated with DCV plasma levels was the  presence of MET. The reason for this increased DCV exposure is unclear; on the clinical side, we have not observed significant adverse events related to the reduction or increase of MET plasma levels. The administration of MET in patients with advanced fibrosis or cirrhosis leads to an early incr ease of DCV plasma level without significant clinical effects or toxicity.Eur Addict Res 2018;24:184 –188
Source: European Addiction Research - Category: Addiction Source Type: research

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Alcohol Damage to the Liver – What Happens? Alcohol use disorder and heavy drinking present many harmful health risks. They can include everything from high blood pressure to fatal seizures. One of the most well-known health risks that come along with prolonged heavy drinking is liver damage. How does alcohol impact the liver, and what types of alcohol damage to the liver are there? In order to better understand alcohol damage to the liver, it is important to learn how the liver processes alcohol. According to MyDr, there are 2 ways that alcohol can be processed by your liver: Most alcohol is broken down, or metabol...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Alcohol Alcohol Rehab Information Alcoholism Detox Resources for Alcohol and Drugs/Opiates alcohol abuse alcohol dependence alcohol detox alcohol treatment alcohol treatment center alcohol treatment facility Source Type: blogs
Conclusions: LT candidates without known alcohol or drug use may have a clinically significant consumption of alcohol and previous illicit drug use. Efforts should be put on identification of these patients during LT evaluation. The use of structured questionnaires such as the ASI and the LDH could facilitate detection of alcohol and drug problems. PMID: 31453745 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
CONCLUSIONS: We found low to very low-quality evidence to suggest that there is no difference in effectiveness between different types of psychosocial interventions to reduce alcohol consumption among people who use illicit drugs, and that brief interventions are not superior to assessment-only or to treatment as usual. No firm conclusions can be made because of the paucity of the data and the low quality of the retrieved studies. PMID: 30521696 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
Conclusion As this was only a pilot study, further data collection involving a larger, representative sample of clients should be undertaken to explore these results further. References Bennett, H. et al., 2015. Assessing the Long-Term Impact of Treating Hepatitis C Virus (HCV)-Infected People Who Inject Drugs in the UK and the Relationship between Treatment Uptake and Efficacy on Future Infections. PLoS ONE, 10(5), p.e0125846. Edeghere, O. et al., 2015. Retrospective cohort study of liver transplantation in the United Kingdom between 1994 and 2010: the impact of hepatitis C infection. Public Health, 129(5), pp.509–5...
Source: Alcohol Research UK - Category: Addiction Authors: Tags: Alcohol Insights Source Type: news
Conclusion A high proportion of PWUD had significant fibrosis or cirrhosis that were associated with cHCV infection, HIV/HCV coinfection and duration of heavy alcohol drinking. Increased uptake of HCV treatment and interventions to reduce alcohol use are needed to decrease the liver disease burden in this population.
Source: European Journal of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research
Conclusions: SVR was not significantly associated with sociodemographic or virological characteristics, treatment, social environment, alcohol/drug use, and adherence. Although adherence was slightly worse than in “usual” patients, it did not affect the SVR rate. In these difficult-to-manage patients with HCV and substance use disorder, the real-world SVR rate (90%) was similar to that in nonaddicted populations.
Source: Journal of Addiction Medicine - Category: Addiction Tags: Original Research Source Type: research
This study compared sustained virological response (SVR) rates and proportion of lost to follow‐up (LTFU) between OST and non‐OST patients in the German Hepatitis C‐Registry (DHC‐R). DesignNational multi‐centre prospective real‐world registry (German Hepatitis C‐Registry, DHC‐R). Non‐OST patients comprised patients with former/current drug use (non‐OST/DU) and patients never consuming drugs (non‐OST/NDU). SettingA total of 254 medical centres in Germany, including 123 centres providing OST. ParticipantsA total of 7747 chronic HCV patients started DAA therapy (739 OST and 7008 non‐OST; 1500 non‐OST...
Source: Addiction - Category: Addiction Authors: Tags: Research Report Source Type: research
CA Abstract BACKGROUND: In Switzerland, intravenous drug use accounts for the majority of hepatitis C virus (HCV) infections. Early HCV treatment prevents further transmissions and reduces morbidity and mortality due to decompensated liver cirrhosis and hepatocellular carcinoma. Nevertheless, patients in drug substitution programmes are often insufficiently screened and treated. AIM: The aim was to compare the current state of HCV management in centralised and decentralised drug substitution programmes of the canton Aargau. Objectives were human immunodeficiency virus (HIV) and HCV prevalence, compliance wit...
Source: Swiss Medical Weekly - Category: General Medicine Authors: Tags: Swiss Med Wkly Source Type: research
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Source: Journal of Viral Hepatitis - Category: Infectious Diseases Authors: Tags: Letter Source Type: research
Abstract BACKGROUND and AIMSAlcohol use disorders (AUDs) are common among people with chronic hepatitis C (HCV) and accelerate the development of fibrosis and cirrhosis caused by HCV. Baclofen, a gamma‐aminobutyric acid (GABA) beta‐receptor agonist, differs from medications for AUDs currently approved by the United States (US) Federal Drug Administration (FDA) as it is metabolized primarily through the kidneys. The primary outcome of this study was to compare baclofen with a placebo in the percentage of days abstinent from alcohol. DESIGNA double‐blind, placebo‐controlled randomized trial. SETTINGHepatology clinics...
Source: Addiction - Category: Addiction Authors: Tags: Research Report Source Type: research
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