Synthesis at the interface of virology and genetic code expansion.

Synthesis at the interface of virology and genetic code expansion.
Curr Opin Chem Biol. 2018 Aug 04;46:164-171
Authors: Kelemen RE, Erickson SB, Chatterjee A
Abstract
How a virus efficiently invades its host cell and masterfully engineers its properties provides valuable lessons and resources for the emerging discipline of synthetic biology, which seeks to create engineered biological systems with novel functions. Recently, the toolbox of synthetic biology has also been enriched by the genetic code expansion technology, which has provided access to a large assortment of unnatural amino acids with novel chemical functionalities that can be site-specifically incorporated into proteins in living cells. The synergistic interplay of these two disciplines holds much promise to advance their individual progress, while creating new paradigms for synthetic biology. In this review we seek to provide an account of the recent advances at the interface of these two research areas.
PMID: 30086446 [PubMed - as supplied by publisher]

Source: Current Opinion in Chemical Biology - August 4, 2018 Category: Biochemistry Authors: Kelemen RE, Erickson SB, Chatterjee A Tags: Curr Opin Chem Biol Source Type: research