[ASAP] A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 < italic toggle="yes" > H < /italic > ,2 < italic toggle="yes" > H < /italic > ,3 < italic toggle="yes" > H < /italic > -pyrrolo[3,2- < italic toggle="yes" > b < /italic > ]pyridin-1-yl)-2-[(2 < italic toggle="yes" > R < /italic > ,5 < italic toggle="yes" > R < /italic > )-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660)

Journal of Medicinal ChemistryDOI: 10.1021/acs.jmedchem.8b00900

Source: Journal of Medicinal Chemistry - August 9, 2018 Category: Chemistry Authors: Christopher N. Johnson, Jong Sook Ahn, Ildiko M. Buck, Elisabetta Chiarparin, James E. H. Day, Anna Hopkins, Steven Howard, Edward J. Lewis, Vanessa Martins, Alessia Millemaggi, Joanne M. Munck, Lee W. Page, Torren Peakman, Michael Reader, Sharna J. Rich, Source Type: research