Daytime Midpoint as a Digital Biomarker for Chronotype in Bipolar Disorder

Sleep disturbance is a pervasive and persistent phenomenon in bipolar disorder (BD), experienced by between 70-99% of BD patients (Harvey, Talbot,& Gershon, 2009). Abnormalities in sleep quality, as well as circadian rhythm irregularities, may be markers of current or imminent manic or depressive episodes (Cretu, Culver, Goffin, Shah,& Ketter, 2016; Gershon et al., 2017; Perlman, Johnson,& Mellman, 2006), or future positive or negative affect (Kaufmann, Gershon, Eyler,& Depp, 2016), and therefore are important markers for monitoring BD course and treatment progress.
Source: Journal of Affective Disorders - Category: Neurology Authors: Tags: Research paper Source Type: research