Low brain-derived neurotrophic factor levels in post-mortem brains of older adults with depression and dementia in a large clinicopathological sample.

Depression in older adults is a heterogeneous disorder with complex and multiple pathogenic mechanisms. Many studies have explored the vascular component of depression in older adults (Aizenstein et al., 2016). In contrast, few studies on the basis of the neurotrophin hypothesis, which is one of the main hypotheses of adult depression at the present day, have been conducted in older persons with depression. These few studies focused mostly on peripheral measurements of neurotrophins (Hashizume et al., 2015).

Source: Journal of Affective Disorders - August 9, 2018 Category: Neurology Authors: Paula Villela Nunes, Camila Fernandes Nascimento, Helena Kyunghee Kim, Ana Cristina Andreazza, Helena Paula Brentani, Claudia Kimie Suemoto, Renata Elaine Paraizo Leite, Renata Eloah de Lucena Ferretti-Rebustini, Carlos Augusto Pasqualucci, Ricardo Nitrin Tags: Research paper Source Type: research