Habenular Connectivity May Predict Treatment Response in Depressed Psychiatric Inpatients

The habenula (Hb) is a diencephalic structure bilaterally positioned on either side of the third ventricle. It is composed of paired nuclei —medial and lateral—which differ in several characteristics including afferent/efferent connectivity (Klemm, 2004) and transcriptome (Lein et al., 2007). The nuclei receive inputs largely through the stria medullaris from the limbic-forebrain and basal ganglia and they project their output th rough the fasciculus retroflexus to several brainstem nuclei (Bianco and Wilson, 2009; Hikosaka et al., 2008; Omelchenko et al., 2009; Sesack and Grace, 2010).

Source: Journal of Affective Disorders - August 9, 2018 Category: Neurology Authors: Savannah N. Gosnell, Kaylah N. Curtis, Kenia Velasquez, J. Christopher Fowler, Alok Madan, Wayne Goodman, Ramiro Salas Tags: Research paper Source Type: research