HOW TO Evaluate Medical Apps, Health Technologies, and Websites

How do you decide what’s real or fake news on the internet? How do you evaluate the quality of medical apps or health technologies? As part of our From Chance To Choice campaign, we would like to help medical professionals make a more informed judgment about digital health tools so they would be more confident – and perhaps more open – to talk about online diagnostic means, medical apps, sensors or wearables. Thus, they could successfully navigate their patients in the jungle of digital health – and proudly wear the Ask Me About Digital pin on their coats (yes, we already have that, too!) Ode against the fake, the viral and the hoax The era of fake news, spam emails, scams, online conspiracy theories, internet trolls are upon us. We were tempted to cite and link dozens of poorly written, fake pieces that went viral – but we did not want to create another online corner for increasing the readership numbers of pizzagate (the debunked conspiracy theory falsely linking the Democrats to several restaurant chains). We know someone might look up the term, but don’t do it if you want to fight against the spread of fake news! Go against the snowball effect! That means sensationalist, click-bait titles with half-truths or make-believe statements get more clicks, more likes and more shares, which means better visibility – even more likes, clicks, and shares. These pieces reach people in the thousands who tend to remember and believe them, especi...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: From Chance to Choice Health Sensors & Trackers Medical Professionals Patients Social media in Healthcare apps digital digital health digital technology fake news health apps Innovation wearables websites Source Type: blogs

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In this study, we found that TLR1/TLR2 expression predicted favorable prognosis of lung cancer patients. In the related mice tumor model, TLR1/TLR2 activation by synthetic bacterial lipoprotein (BLP), a TLR1/2 agonist, greatly inhibited tumor growth and selectively decreased monocytic MDSCs (M-MDSCs). Furthermore, BLP treatment redirected M-MDSC differentiation towards M1 macrophage through JNK pathway, and thus blocked the suppressive activity of M-MDSCs in a TLR2-dependent manner. Therefore, our data demonstrated that TLR2 could be a promising biomarker and a potential immunotherapeutic target for lung cancer.
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
Publication date: August 2019Source: Molecular Immunology, Volume 112Author(s): Elizabeth A. Bemis, Jill M. Norris, Jennifer Seifert, Ashley Frazer-Abel, Yuko Okamoto, Marie L. Feser, M. Kristen Demoruelle, Kevin D. Deane, Nirmal K. Banda, V. Michael HolersAbstractRheumatoid arthritis (RA) is a complex autoimmune disease with an etiology that is not yet well understood, disproportionally affects women and also varies in incidence and prevalence by population. The presence of anti-citrullinated protein antibodies (ACPA) is a highly specific biomarker for the diagnosis of clinically apparent RA. ACPA are also present in the ...
Source: Molecular Immunology - Category: Allergy & Immunology Source Type: research
Publication date: Available online 14 June 2019Source: Stem Cell ResearchAuthor(s): Nutnicha Tantarungsee, Zaukir Bostan Ali, Rungtip Soi-ampornkul, Chuda Rujitharanawong, Chanika Subchookul, Alisa Ritthaphai, Bootsakorn Boonkaew, Methichit Wattanapanitch, Kanchalit Thanomkitti, Daranporn Triwongwaranat, Chinnavuth Vatanashevanopakorn, Rattapon ThuangtongAbstractAn induced pluripotent stem cell (iPSC) line, MUSIi010-A, was established by Sendai virus (SeV) transduction of scalp fibroblasts from a 59-year-old male with androgenetic alopecia (AGA). Pluripotency of the iPSC line was verified by immunofluorescence staining of ...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 15 June 2019Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Yang Xiong, Ying Wang, Karthik TiruthaniAbstractColorectal cancer (CRC) is predicted to be the 2nd leading cause of cancer-related death in United States in 2019. Immunotherapies such as checkpoint inhibitors have proven efficacy in patients with high level of microsatellite instability and refractory to routine chemotherapy. Despite this, immunotherapy-based treatment is seriously limited by cancer immunogenicity which are evolved to evade immune surveillance in many circumstances. Efforts are made by resear...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - Category: Nanotechnology Source Type: research
Publication date: Available online 15 June 2019Source: Nano TodayAuthor(s): Weijing Yang, Zijian Zhou, Joseph Lau, Shuo Hu, Xiaoyuan ChenAbstractImmunotherapy (e.g., checkpoint blockade, adoptive T cell therapy, cancer vaccine) has emerged as one of the most important treatment modalities for cancer in the past two decades. While these approaches are promising, the response rates observed in clinical trials are less than 30% due to tumor heterogeneity and complexity of the tumor microenvironment. Smart nanosystems have the potential to address some of the limitations associated with immunotherapy. Herein, we review applica...
Source: Nano Today - Category: Nanotechnology Source Type: research
Publication date: August 2019Source: Clinica Chimica Acta, Volume 495Author(s): Yujia He, Abidali Mohamedali, Canhua Huang, Mark S. Baker, Edouard C. NiceAbstractOncoproteomics is the systematic study of cancer samples using omics technologies to detect changes implicated in tumorigenesis. Recent progress in oncoproteomics is already opening new avenues for the identification of novel biomarkers for early clinical stage cancer detection, targeted molecular therapies, disease monitoring, and drug development. Such information will lead to new understandings of cancer biology and impact dramatically on the future care of can...
Source: Clinica Chimica Acta - Category: Laboratory Medicine Source Type: research
Abstract Base excision DNA repair (BER) is a vitally important pathway that protects the cell genome from many kinds of DNA damage, including oxidation, deamination, and hydrolysis. It involves several tightly coordinated steps, starting from damaged base excision and followed by nicking one DNA strand, incorporating an undamaged nucleotide, and DNA ligation. Deficiencies in BER are often embryonic lethal or cause morbid diseases such as cancer, neurodegeneration, or severe immune pathologies. Starting from the early 1980s, when the first mammalian cell lines lacking BER were produced by spontaneous mutagenesis, s...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
This study demonstrates that NSCLC cells resistant to gefitinib (GR cells) displayed a significantly higher microsomal prostaglandin E synthase-1 (mPGES-1) expression and activity than parental cells. Overexpression of mPGES-1/prostaglandin E-2 (PGE-2) signaling in GR cells was associated with acquisition of mesenchymal and stem-like cell properties, nuclear EGFR translocation and tolerance to cisplatin. mPGES-1 inhibition reduced mesenchymal and stem-like properties, and nuclear EGFR translocation in GR cells. Consistently, inhibition of mPGES-1 activity enhanced sensitivity to cisplatin and responsiveness to gefitinib in...
Source: Prostaglandins and Other Lipid Mediators - Category: Lipidology Source Type: research
Conclusion: This study showed that periodontal diseases were associated with increased risk of several cancers. Besides other wellknown benefits for health, the provision of oral/dental health should be considered and employed as a cancer prevention measure. PMID: 31195790 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
Authors: Yıldız Çeltek N, Süren M, Demir O, Okan İ Abstract Background/aim: Validated measures in palliative cancer patients are very important in the evaluation and management of the disease. The Karnofsky Performance Scale (KPS) has been used for many years to assess the performance status of cancer patients. The aim of this study is to determine the validity and reliability of the KPS in cancer patients receiving palliative care in Turkey. Materials and methods: Eighty patients with a cancer diagnosis who were admitted to Gaziosmanpaşa University Medical Faculty Hospital Palliative Care Unit ...
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
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