Anti-HBc Quantitation as a New Biomarker of Hepatitis B Virus Infection: Surrogate Markers Predicting Surrogate Endpoints

Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research

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THE GORDON WILSON LECTURE: THE HEPATITIS C VIRUS: FROM HIPPOCRATES TO CURE. Trans Am Clin Climatol Assoc. 2019;130:104-118 Authors: Alter HJ Abstract The modern age of viral hepatitis began in the early 1960s with the serendipitous discovery of the Australia antigen, a protein that was later shown to represent the envelope of the hepatitis B virus leading to its designation as the hepatitis B surface antigen. This was the first marker for any hepatitis virus and became not only a diagnostic assay, but also a mandatory blood donor screening test and the basis for the first generation hepatitis B vaccine...
Source: Transactions of the American Clinical and Climatological Association - Category: General Medicine Tags: Trans Am Clin Climatol Assoc Source Type: research
From the Karolinska Institute in Stockholm, Vincent speaks with Niklas Björkström, Ali Mirazimi, and Matti Sällberg about their work on the impact of chronic hepatitis C virus infection on NK cells, Crimean-Congo hemorrhagic fever virus vaccines, and immunotherapy to block entry of hepatitis B and D viruses. Click arrow to play Download TWiV 565 (52 MB .mp3, […]
Source: virology blog - Category: Virology Authors: Tags: This Week in Virology Crimean-Congo hemorrhagic fever virus dna vaccine hepatitis b virus hepatitis C virus hepatitis D virus immunotherapy Karolinska Institute NK cell T cell exhaustion treatment interruption viral viruses Source Type: blogs
From the Karolinska Institute in Stockholm, Vincent speaks with Niklas Björkström, Ali Mirazimi, and Matti Sällberg about their work on the impact of chronic hepatitis C virus infection on NK cells, Crimean-Congo hemorrhagic fever virus vaccines, and immunotherapy to block entry of hepatitis B and D viruses. Hosts: Vincent Racaniello Guests: Niklas Björkström, Ali Mirazimi, and Matti Sällberg Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Karolinska Huddinge CCHV experimental vaccines (J Virol) Incre...
Source: This Week in Virology - MP3 Edition - Category: Virology Authors: Source Type: podcasts
In conclusion, this study provided a comprehensive overview of the current circulation of HBV subgenotypes in Brazil. Our findings might contribute to a better understand of the dynamics of viral variants, to establish a permanent molecular surveillance on the introduction and dispersion patterns of new strains and, thus, to support public policies to control HBV dissemination in Brazil.
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Authors: Onitsuka K, Tokuda R, Kuwata-Higashi N, Kumamoto H, Aoki M, Amano M, Kohgo S, Das D, Haraguchi K, Mitsuya H, Imoto S Abstract Hepatitis B virus (HBV) infection is a major worldwide health problem that requires the development of improved antiviral therapies. Here, a series of 4'-Azido-thymidine/4'-Azido-2'-deoxy-5-methylcytidine derivatives (6, 10-15) were synthesized, and their anti-HBV activities evaluated. Compounds 10-15 were synthesized via an SNAr reaction of 18, in which the 4-position of the thymine moiety was activated as the 2,4,6-triisopropylbenzenesulfonate. Compounds 11-15 showed no antiviral ...
Source: Nucleosides, Nucleotides and Nucleic Acids - Category: Biochemistry Tags: Nucleosides Nucleotides Nucleic Acids Source Type: research
ConclusionWe believe that these efforts will help to significantly improve the gastrointestinal cancer treatment and survival.
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
egini It is well known that hepatitis B virus reactivation (HBVr) can occur among patients undergoing treatment for hematological malignancies (HM). The evaluation of HBVr risk in patients undergoing immunosuppressive treatments is a multidimensional process, which includes conducting an accurate clinical history and physical examination, consideration of the virological categories, of the medication chosen to treat these hematological malignancies and the degree of immunosuppression induced. Once the risk of reactivation has been defined, it is crucial to adopt adequate management strategies (should reactivation occur...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
Publication date: Available online 12 September 2019Source: Journal of Fluorine ChemistryAuthor(s): V.A. Likholobov, L.G.P’ yanova, A.M. Danilenko, T.S. Godovikova, A.V. SedanovaAbstractThe study deals with the development of selective sorbents that are able to remove viral particles, particularly the hepatitis B surface antigen (HBsAg), from blood serum of patients infected with hepatitis B virus (HBV). The hemosorbents were obtained by modification with gas-phase fluorine and BrF3 solutions in HF and subsequent substitution of fluorine by amino groups. Polyalbumin (PA) (human serum albumin (HSA) modified with gluta...
Source: Journal of Fluorine Chemistry - Category: Chemistry Source Type: research
Publication date: 2019Source: European Urology Supplements, Volume 18, Issue 4Author(s): J. Yang
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
Conclusions: In HIV-1–infected subjects with AHB, the persistence of HBsAg seemed to occur frequently. Factors associated with a lower CBI risk were detectable HIV load and the use of dually acting antiretroviral treatment during AHB.
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - Category: Infectious Diseases Tags: Clinical Science Source Type: research
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