Nanoparticle therapy could deliver double blow to cancer

(University of East Anglia) A new cancer therapy using nanoparticles to deliver a combination therapy direct to cancer cells could be on the horizon.Using nanoparticles to get drugs directly into a tumor is a growing area of cancer research. The technology developed at UEA is the first of its kind to use nanoparticles to deliver two drugs in combination to target cancer cells. The therapy has been shown to make breast cancer and prostate cancer tumors more sensitive to chemotherapy.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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Authors: Zhao L, Zhou S, Gustafsson JÅ Abstract Nuclear receptors (NRs) are transcription factors actively involved in many aspects of human physiology and pathology, serving as sensors of stimuli, master regulators of downstream molecular events and hubs governing complex gene regulatory networks. The importance of various members of the NR superfamily in cancer has led to substantial efforts to target them therapeutically. Notably, drugs that block the action of estrogen receptor alpha (ERα) in patients with ERα+ breast cancer or the androgen receptor (AR) in prostate cancer patients have provid...
Source: Endocrine Reviews - Category: Endocrinology Tags: Endocr Rev Source Type: research
eok Ahn Capsazepine is a synthetic analogue of capsaicin that can function as an antagonist of TRPV1. Capsazepine can exhibit diverse effects on cancer (prostate cancer, breast cancer, colorectal cancer, oral cancer, and osteosarcoma) growth and survival, and can be therapeutically used against other major disorders such as colitis, pancreatitis, malaria, and epilepsy. Capsazepine has been reported to exhibit pleiotropic anti-cancer effects against numerous tumor cell lines. Capsazepine can modulate Janus activated kinase (JAK)/signal transducer and activator of the transcription (STAT) pathway, intracellular Ca2+ conc...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
CONCLUSION: Apoptosis was enhanced and mitochondria function was deteriorated by DOX treatment, resulting in muscle weakness and central fatigue. Treadmill exercise suppressed apoptosis and prevented deterioration of mitochondria function in muscle, resulting in alleviation of muscle weakness and central fatigue during DOX therapy. PMID: 30832465 [PubMed]
Source: International Neurourology Journal - Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research
Conditions:   Solid Tumors;   Advanced Triple Negative Breast Cancer;   Advanced Hormone Receptor Positive/Endocrine Refractory Breast Cancer;   Advanced Metastatic Castration-Resistant Prostate Cancer;   Advanced Platinum-Resistant Ovarian Cancer Interventions:   Drug: TRX518;   Drug: Cyclophosphamide;   Drug: Avelumab Sponsors:   Leap Therapeutics, Inc.;   Pfizer;   Merck KGaA, Darmstadt, Germany Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionThese cancer incidence projections up to 2042 can be used for planning cancer control strategies and prevention programs. Given the ongoing changes in the prevalence of risk factors and in cancer prevention policies, these estimates should be interpreted with caution.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
(Natural News) Breast cancer has long been one of the most common cancers, as well as one of the biggest killers. But in the United Kingdom, prostate cancer has turned into an even bigger threat. As the Daily Mail reports, nearly 12,000 U.K. men are losing their lives to prostate cancer annually. More, the disease has...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Publication date: Available online 27 February 2019Source: Pathology - Research and PracticeAuthor(s): Bifeng Chen, Yuwei Jiao, Fukang Yaolong, Tiansong Li, Yuxiao Liu, Meiqin Wang, Gu Xiuli, Xianhong FengAbstractThe rs3787016 polymorphism, in polymerase II polypeptide E (POLR2E), was previously identified as being associated with the risk for prostate cancer, esophageal cancer, breast cancer, papillary thyroid carcinoma and liver cancer, suggesting that rs3787016 may server as a common genetic factor to affect individual susceptibility to cancer. To prove the hypothesis, we here performed a case-control study to explore t...
Source: Pathology Research and Practice - Category: Pathology Source Type: research
(Natural News) Over 5.5 million Americans – mostly over the age of 65 – are battling Alzheimer’s disease, a debilitating condition that kills more people than breast cancer and prostate cancer combined. Alzheimer’s progressively destroys memory and other cognitive functions, causing confusion, anxiety and heartache. The number of people fighting this disease has increased by...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Conclusionsl-1-[18F]FETrp highly accumulated in a wide range of malignancies including lung cancer, prostate cancer, and glioma. These results suggested thatl-1-[18F]FETrp is a promising radiotracer for PET imaging of cancer.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
Abstract The rs3787016 polymorphism, in polymerase II polypeptide E (POLR2E), was previously identified as being associated with the risk for prostate cancer, esophageal cancer, breast cancer, papillary thyroid carcinoma and liver cancer, suggesting that rs3787016 may server as a common genetic factor to affect individual susceptibility to cancer. To prove the hypothesis, we here performed a case-control study to explore the association between rs3787016 and cervical cancer risk, and to confirm the association between rs3787016 and breast cancer in a central Chinese population, which was followed by a meta-analysi...
Source: Pathology, Research and Practice - Category: Pathology Authors: Tags: Pathol Res Pract Source Type: research
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