Frequent HPV-independent p16/INK4A overexpression in head and neck cancer
Human papillomavirus (HPV), in particular the HPV16 subtype, represents a major independent risk factor for oropharyngeal carcinoma (OPSCC), a group of head and neck squamous cell cancers (HNSCC) affecting the tonsils and base of tongue [1 –3]. This is a rapidly evolving cancer in the Western world, with rising trends particularly in the young [4,5]. The most commonly used biomarker for HPV (+) HNSCC in the clinical setting at present is p16INK4A (p16), encoded by the CDKN2A gene (cyclin-dependent kinase (CDK) inhibitor 2A).
Source: Oral Oncology - Category: Cancer & Oncology Authors: Matt Lechner, Ankur R. Chakravarthy, Vonn Walter, Liam Masterson, Andrew Feber, Amrita Jay, Paul M. Weinberger, Richard A. McIndoe, Cillian T. Forde, Kerry Chester, Nicholas Kalavrezos, Paul O'Flynn, Martin Forster, Terry M. Jones, Francis M. Vaz, D. Neil Source Type: research
More News: Cancer | Cancer & Oncology | Carcinoma | Genetics | Genital Warts | Head and Neck Cancer | HNSCC | Human Papillomavirus (HPV) | Oral Cancer | Oropharyngeal Cancer | Squamous Cell Carcinoma | Tonsillitis