Validation and assessment of discordance of the 8th edition AJCC (American Joint Committee on Cancer) clinical and pathologic staging systems in patients with p16+ oropharyngeal cancer treated with surgery and adjuvant radiation at a single institution

Major updates have been made in the latest (8th) edition of the American Joint Commission on Cancer (AJCC) manual for staging of oropharynx squamous cell cancer (OPSCC) [1,2] which are based on changes in epidemiology of OPSCC related to the emergence of Human Papilloma Virus (HPV) as the major cause for OPSCC [3,4]. It is now recognized that patients with HPV positive oropharyngeal cancer (HPV+OPSCC) have superior survival compared to patients with HPV negative oropharynx cancer (HPV −OPSCC) [5].
Source: Oral Oncology - Category: Cancer & Oncology Authors: Source Type: research