Synthesis of 2-substituted 3-chlorobenzofurans via TMSCl-mediated nucleophilic annulation of isatin-derived propargylic alcohols

Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01731J, PaperZhou Sun, Kuirong Xiang, Hua Tao, Liqun Guo, Ying Li A TMSCl-mediated cascade annulation of isatin-derived propargylic alcohols for the synthesis of 2-substituted 3-chlorobenzofurans is now reported. Mechanistic investigations showed that this proceeded through a sequential Meyer –Schuster rearrangement/nucleophilic addition/intramolecular annulation.... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Organic and Biomolecular Chemistry - Category: Molecular Biology Authors: Source Type: research