Idiopathic intracranial hypertension in a mother and pre-pubertal twins

Source: Neuro-Ophthalmology - Category: Opthalmology Authors: Source Type: research

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Publication date: May 2020Source: Biomedicine &Pharmacotherapy, Volume 125Author(s): Juan Li, Min Jia, Manling Liu, Zhi Cao, Xinju Wang, Na Feng, Xiaoming Gu, Shumiao Zhang, Rong Fan, Haitao Guo, Yuemin Wang, Mingchao Liu, Jianming PeiAbstractκ-opioid receptor (κ-OR) plays a key role in preventing hypoxic pulmonary hypertension (HPH) development after activated by exogenous agonist U50,488H. Calcium sensing receptor (CaSR) activation induces HPH by promoting vasoconstriction and vascular remodeling. The activated κ-OR is reported to inhibit the expression of CaSR in pulmonary artery smooth muscle cell...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 14 February 2020Source: Journal of Molecular StructureAuthor(s): Jinmiao Zhang, Maoyu Zhang, Jinying Yu, Yanguo Shang, Kaixuan Jiang, Yihe Jia, Jinxin Wang, Kan YangAbstractSphingosine 1-phosphate (S1P) is a lipid signaling molecule that is implicated in a variety of pathologies, including cancer, inflammation and pulmonary arterial hypertension. Sphingosine kinases (SPHK1 and SPHK2) are the key targets in the synthesis of S1P. However, selective and potent inhibitors of SPHK are lacking, especially for SPHK2. In this work, we predicted the detailed interactions between the inhibitors and...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Drug firms Unichem Pharmaceuticals and Macleods Pharma are recalling various lots of tablets used for treatment of high blood pressure and diabetes from the US market, according to a latest enforcement report of the American health regulator.
Source: The Economic Times Healthcare and Biotech News - Category: Pharmaceuticals Source Type: news
Authors: Akkemik O, Kazaz H, Tamsel S, Dündar N, Sahinalp S, Ellidokuz H Abstract OBJECTIVE: To evaluate the diagnostic accuracy of digital panoramic radiograph (DPR) for detection of carotid artery calcification (CAC) confirmed by Doppler Ultrasonography (DUSG) and to clarify the relationship between between CAC identified by DPR and cardiovascular events through a 5 year follow-up period. METHODS: Of 3600 consecutive patients examined, 158 patients presented with CAC as detected by DPR. The final study group was composed of 96 patients who had CAC confirmed by DUSG or CT angiogram. The control gro...
Source: Dentomaxillofacial Radiology - Category: Radiology Tags: Dentomaxillofac Radiol Source Type: research
Conclusions: PCV in Congolese patients showed features that are more similar to those observed in Caucasians. In this setting where indocyanine green angiography is not available, OCT facilitates the diagnosis of PCV. PMID: 32051763 [PubMed]
Source: Journal of Ophthalmology - Category: Opthalmology Tags: J Ophthalmol Source Type: research
ACI patients with AR have a higher plasma 4 ‐HNE level, suggesting that 4‐HNE may be a factor contributing to aspirin resistance. And AR has a higher CI recurrence rate compared with the patients without AR. AbstractObjectivesTo investigate the association of aspirin resistance (AR) with the plasma 4 ‐hydroxynonenal (4‐HNE) level and its impact on recurrent cerebral infarction (CI) in patients with acute cerebral infarction (ACI) who were receiving aspirin therapy.MethodsOne hundred and fifty ‐four ACI patients who previously received aspirin therapy (100 mg/day) were enrolled. Whole urine (for measuring 11d...
Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Publication date: Available online 14 February 2020Source: Pharmacological ResearchAuthor(s): Lukasz Huminiecki, Atanas G. Atanasov, Jarosław HorbańczukAbstractResveratrol, a phytoalexin, is a natural polyphenol synthesized exclusively by plants in response to environmental stresses. However, the molecule has also many exogenous bioactivities in animal cells. These bioactivities may lead to anti-cancer and cardio-protective health benefits. Because cellular responses to the treatment with resveratrol include the changes of expression patterns, functional genomics is an attractive tool to study them. In recent and today&r...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Conclusion: Candidates for bariatric/metabolic surgery favored SG followed by AGB, GP, and RYGB, and their choices were compatible with current evidence-based clinical practice. PMID: 32051816 [PubMed]
Source: Annals of Surgical Treatment and Research - Category: Surgery Tags: Ann Surg Treat Res Source Type: research
In conclusion, current evidences indicate the need to monitor UPF intake in global population. However, more studies are necessary to interpret better these associations with similar methodologies used in the studies. As well as longitudinal analyses can help to improve comparisons between outcomes and establish cause-effect relationship between UPF intake and cardiometabolic risk. PMID: 32053758 [PubMed - as supplied by publisher]
Source: International Journal of Food Sciences and Nutrition - Category: Nutrition Tags: Int J Food Sci Nutr Source Type: research
HIGH blood pressure puts unnecessary strain on your heart and arteries. Dubbed "the silent killer", this dangerous condition needs to be managed well. Which fruit has been shown to help lower blood pressure readings?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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