Transient Daily Episodes of Vision Loss Due to Parkinson ’s Disease

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Source: Neuro-Ophthalmology - Category: Opthalmology Authors: Source Type: research

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In this study, levels of serine 129-phosphorylated α-syn (pS-α-syn), a major pathologic form of α-syn, in red blood cells (RBCs), were measured using ELISA in a Chinese cohort consisting of 107 MSA patients and 220 healthy controls. A significant increase in the levels of pS-α-syn in RBCs (pS-α-syn-RBC) was observed in MSA patients than in healthy controls (14.02 ± 4.02 ng/mg versus 11.89 ± 3.57 ng/mg; p
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
Authors: Schmitt AC, Baudendistel ST, Fallon MS, Roper JA, Hass CJ Abstract Gait impairment and increased gait variability are common among individuals with Parkinson's disease (PD) and have been associated with increased risk for falls. The development of composite scores has gained interest to aggregate multiple aspects of gait into a single metric. The Enhanced Gait Variability Index (EGVI) was developed to compare an individual's gait variability to the amount of variability in a healthy population, yet the EGVI's individual parts may also provide important information that may be lost in this conversion. We so...
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
Conclusions: The present study showed that NW training had a beneficial effect on FOG in PD and that the achieved improvement is long-lasting. Future research should clarify whether the observed improvement limited to FoG triggered by only some circumstances reflects different pathomechanisms of FoG subtypes. PMID: 32089815 [PubMed]
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
The aggregation of misfolded proteins is a feature of most neurodegenerative conditions: amyloid-β and tau in Alzheimer's disease, α-synuclein in Parkinson's disease, and so forth. These and a few more of the countless proteins present in the body can become altered, such as via misfolding, in ways that encourage other molecules of the same protein to also alter, forming structures of linked, harmful proteins that can spread through tissue or from cell to cell. Cells, particularly immune cells, are equipped with a range of mechanisms to identify and break down these problem proteins, but, for reasons that are no...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Condition:   Parkinson Disease Intervention:   Behavioral: Treadmill walking Sponsors:   Northwestern University;   University of Pittsburgh Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Wnt signaling is a complicated but well studied portion of the regulatory systems governing regeneration. Numerous groups are engaged in the commercial development of regenerative therapies that are based on manipulation of this part of mammalian biochemistry. Of the more prominent ventures, Samumed has reached phase 3 trials with treatments of this type. This open access paper walks through the evidence for Wnt signaling to be a useful point of intervention for researchers aiming to increase neurogenesis and regenerative capacity in the aging brain. This will be developed as a means of treating neurodegenerative condition...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
Conclusionsα-HgS-containing Hua-Feng-Dan and β-HgS-containing 70W at clinical doses protected against chronic LPS plus MPTP-induced toxicity to the brain and gut, suggesting HgS-containing traditional medicines could target gut microbiota as a mechanism of their therapeutic effects.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 24 February 2020Source: Stem Cell ResearchAuthor(s): L.D. Shuvalova, A.V. Eremeev, A.N. Bogomazova, E.V. Novosadova, E.A. Zerkalenkova, Yu. V Olshanskaya, E.Y. Fedotova, E.S. Glagoleva, S.N. Illarioshkin, O.S. Lebedeva, M.A. LagarkovaAbstractIPSC line RCPCMi004-A was generated from skin fibroblasts collected from a male patient with early onset Parkinson's disease. The patient carries a heterozygous deletion of the exon 2 of PARK2 gene. The reprogramming of fibroblasts was performed with Sendai viruses containing Oct-4, Sox-2, Klf-4 and c-Myc. Pluripotency was confirmed by immunofluoresce...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Apomorphine sublingual film effectively treated Parkinson disease off-episodes among patients who tolerated the therapy, a multisite trial in The Lancet Neurology reported. The sublingual film is an investigational formulation of apomorphine, an approved Parkinson therapy given by injection.
Source: JAMA - Category: General Medicine Source Type: research
A test that uses samples of cerebrospinal fluid was able to distinguish Parkinson ’s disease from a related condition called multiple system atrophy with 95% accuracy.
Source: NIH Research Matters from the National Institutes of Health (NIH) - Category: Consumer Health News Source Type: news
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