Role of IL-6/IL-10 ratio in the diagnosis and in the assessment of the severity of obsessive-compulsive disorder

AbstractObsessive-compulsive disorder (OCD) has a genetic and environmental pathogenesis. The immunologic changes in OCD have been proven in many studies, but those tackling cytokine in OCD are still limited. The present study aims to evaluate the diagnostic performance of IL-6, IL-10, and the IL-6/IL-10 ratio in the OCD patient group, and to show their correlation with the clinical parameters of OCD. Eighty subjects (60 OCD patients and 20 matched controls) were participating in this study. The enzyme-linked immunosorbent assay was run to quantify the IL-6 and IL-10. Serum IL-6 exhibited a higher result in OCD patients than controls (p = 0.002) but serum IL-10 levels had no significant difference (p >  0.05). IL-6/IL-10 ratio showed significantly higher values in OCD patients than controls (p 
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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Conclusion: Our findings implicate areas previously reported to be involved in OCD, as well as areas not typically implicated in OCD, suggesting that the neurobiological profile of TS+OCD is intermediate to pure TS and pure OCD.
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
This study aimed to examine parents' report of children's emotion regulation (ER) and associations with OCD severity, externalising symptoms, and FA. Participants were 76 youth (7 to 17 years) with a primary diagnosis of OCD and one of their parents. Following child diagnostic and OCD symptom interviews, parents completed study questionnaires. Results indicated that parent-report of children's Lability/Negativity was significantly and positively correlated with child externalising symptoms and FA, whereas children's adaptive ER was significantly and negatively correlated with externalising symptoms only. Furthermore, child...
Source: Journal of Obsessive Compulsive and Related Disorders - Category: Psychiatry Source Type: research
This study offers a promising measure of BSD. Additionally, the results provide support for the importance of buying cognitions, social factors and the motivational importance of buying objects to provide a sense of self worth and certainty to BSD.
Source: Journal of Obsessive Compulsive and Related Disorders - Category: Psychiatry Source Type: research
Severe health anxiety (SHA)/hypochondriasis (HY) is often associated with personality pathology; however, studies report inconsistent results. In general populations, 12% have a personality disorder (PD). We assessed physician-referred psychiatric outpatients with SHA enrolled for a treatment study (n = 84) with the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) axis II (SCID-II), Personality Inventory for DSM-5 (PID-5), Whiteley Index 7, and Short Health Anxiety Inventory, and the healthy controls (n = 84) with PID-5 only. There were 71.4% of the patients who ...
Source: The Journal of Nervous and Mental Disease - Category: Psychiatry Tags: Original Articles Source Type: research
Going through alcohol withdrawal can be an uncomfortable experience. Fortunately there are medical interventions that can ease the symptoms of detox as well as help individuals along their journey through recovery. Medically assisted treatment (MAT) is the use of medications in combination with counseling and behavioral therapies, which is effective in the treatment of substance abuse and can help some people to sustain recovery. Medically assisted treatment for alcohol can help people recovering from alcohol use disorder by blocking cravings, avoiding relapse, and helping to rewire the brain’s chemistry. Medication...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Alcohol Alcohol Rehab Information Alcoholism Detox Resources for Alcohol and Drugs/Opiates alcohol detox drug detox medical detox medicated-assisted detox Source Type: blogs
Authors: Johansen SL, Stenhaug BA, Robakis TK, Williams KE, Cullen MR Abstract OBJECTIVE: To compare risk for postpartum depression across prior psychiatric diagnoses. METHODS: The deidentified Optum© Clinformatics Data Mart of national commercial insurance claims was used to identify 1,166,577 women of reproductive age with first-observed incidence of pregnancy across all 50 United States from 2003 to 2016. Women with insurance coverage for at least 6 months prior to conception and following delivery were eligible (n = 336,522). Psychiatric diagnoses prior to pregnancy were identified by ICD-9-CM and ICD-...
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
This study intends to build on current literature regarding the parental correlates of obsessive-compulsive (OC) symptoms among school-age children by addressing a gap related to the possible relations of parental OC symptoms, parenting stress and dysfunctional caregiving behaviors with the child's OC symptoms. The cross – sectional design involved 113 children (61 female; M age = 11.04 years, SD = 1.00) and their mothers (M age = 41.58 years, SD = 4.60), recruited through schools located in urban areas. Child-reported measures included OC symptoms and perceived mothers' caregiving behavior, while mot...
Source: Journal of Obsessive Compulsive and Related Disorders - Category: Psychiatry Source Type: research
OBJECTIVES: In this retrospective study of patients with obsessive-compulsive disorder (OCD), we assessed the relationship between different motivational drivers of compulsive behaviours and the response to naturalistic treatments (based mostly on high dos...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Conclusions: Psychiatric comorbidity is very common in epileptic patients and depending on the type of diagnosed epilepsy, various symptoms are expressed. Furthermore, psychological stress is more observable in adolescents with epilepsy. For patients with epilepsy, mental health care and seizure control is extremely important in the prevention of serious mental disabilities. PMID: 31961263 [PubMed - as supplied by publisher]
Source: Nordic Journal of Psychiatry - Category: Psychiatry Tags: Nord J Psychiatry Source Type: research
Conclusions: Taken together with our results, our study suggests that dysregulation of the blood-brain barrier, especially claudin-5, may be involved in the etiology of OCD. PMID: 31961248 [PubMed - as supplied by publisher]
Source: Nordic Journal of Psychiatry - Category: Psychiatry Tags: Nord J Psychiatry Source Type: research
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