The Persistent Lyme Disease: “True Chronic Lyme Disease ” rather than “Post-treatment Lyme Disease Syndrome ”
Alexis Lacout, Mostafa El Hajjam, Pierre-Yves Marcy, Christian PerronneJournal of Global Infectious Diseases 2018 10(3):170-171
(Harvard Medical School) A $5 million donation to Harvard Medical School will propel Lyme disease research, education
Publication date: Available online 1 July 2020Source: Ticks and Tick-borne DiseasesAuthor(s): Saied Reza Naddaf, Ahmad Mahmoudi, Ahmad Ghasemi, Mahdi Rohani, Ali Mohammadi, Seyyed Payman Ziapour, Amir Hesam Nemati, Ehsan Mostafavi
Pathogen specific antibody responses need to be tightly regulated to generate protective but limit self-reactive immune responses. While loss of humoral tolerance has been associated with microbial infections, the pathways involved in balancing protective versus autoreactive antibody responses in humans are incompletely understood. Studies in classical mouse model systems have provided evidence that balancing of immune responses through inhibitory receptors is an important quality control checkpoint. Genetic differences between inbred mouse models and the outbred human population and allelic receptor variants not present i...
Title: What Happens if You Go Untreated for Lyme Disease?Category: Diseases and ConditionsCreated: 6/17/2020 12:00:00 AMLast Editorial Review: 6/29/2020 12:00:00 AM
LOW SEROPREVALENCE OF LYME DISEASE AMONG MULTIPLE SCLEROSIS PATIENTS IN NEW BRUNSWICK. Can J Neurol Sci. 2020 Jun 29;:1-11 Authors: MacLean G, Cook P, Lindsay LR, Hatchette TF, Webster D PMID: 32594964 [PubMed - as supplied by publisher]
Authors: Franco-Avecilla D, Yeung C, Baranchuk A PMID: 32575061 [PubMed - in process]
Authors: Semproni M, Rusk R, Wuerz T PMID: 32575059 [PubMed - in process]
LYME disease is a bacterial infection that can be spread to humans by infected ticks, tiny spider-like creatures that dwell in woodland. Untreated Lyme disease can cause a host of debilitating health problems so it is vital to act on the early warning sign.
Compared to the standard two-tiered testing (STTT) algorithm for Lyme disease serology using an enzyme immunoassay (EIA) followed by Western blotting, data from the United States suggest that a modified two-tiered testing (MTTT) algorithm employing two EIAs has improved sensitivity to detect early localized Borrelia burgdorferi infections without compromising specificity. From 2011 to 2014, in the Canadian province of Nova Scotia, where Lyme disease is hyperendemic, sera submitted for Lyme disease testing were subjected to a whole-cell EIA, followed by C6 EIA and subsequently IgM and/or IgG immunoblots on sera with EIA-pos...
Discussion Bradycardia is a heart rate below what the lowest value that is normal for age. Infants and children have higher heart rates that slowly decrease with age to adult levels. It is usually noted as an incidental finding because of increased vagal tone. Reasons for cardiology referral include associated heart murmur, syncope especially if associated with exercise or unusual triggers, other signs such as chest pain or palpitations, family history of sudden cardiac death, congenital heart disease or familial heart disease, bradycardic medication use, or unusual symptoms associated with the concern. Severe bradycardia ...