Interleukin-17 enhances cardiac ventricular remodeling via activating MAPK pathway in ischemic heart failure

We aimed to investigate the impact of interleukin (IL)-17 on ventricular remodeling and the genesis of ventricular arrhythmia (VA) in an ischemic heart failure (HF) model. The expression of the proinflammatory cytokine IL-17 is upregulated during myocardial ischemia and plays a fundamental role in postinfarct inflammation. However, the influence of IL-17 on the genesis of VA has not yet been studied.

Source: Journal of Molecular and Cellular Cardiology - August 7, 2018 Category: Cytology Authors: Shih-Lin Chang, Ya-Wen Hsiao, Yung-Nan Tsai, Shien-Fong Lin, Shuen-Hsin Liu, Yenn-Jiang Lin, Li-Wei Lo, Fa-Po Chung, Tze-Fan Chao, Yu-Feng Hu, Ta-Chuan Tuan, Jo-Nan Liao, Yu-Cheng Hsieh, Tsu-Juey Wu, Satoshi Higa, Shih-Ann Chen Source Type: research