Liquid crystalline bacterial outer membranes are critical for antibiotic susceptibility [Microbiology]

The outer membrane (OM) of Gram-negative bacteria is a robust, impermeable, asymmetric bilayer of outer lipopolysaccharides (LPSs) and inner phospholipids containing selective pore proteins which confer on it the properties of a molecular sieve. This structure severely limits the variety of antibiotic molecules effective against Gram-negative pathogens and, as antibiotic...

Source: Proceedings of the National Academy of Sciences - August 7, 2018 Category: Science Authors: Nicolo Paracini, Luke A. Clifton, Maximilian W. A. Skoda, Jeremy H. Lakey Tags: PNAS Plus Source Type: research