Inferring the shape of global epistasis [Evolution]

Genotype–phenotype relationships are notoriously complicated. Idiosyncratic interactions between specific combinations of mutations occur and are difficult to predict. Yet it is increasingly clear that many interactions can be understood in terms of global epistasis. That is, mutations may act additively on some underlying, unobserved trait, and this trait is then...

Source: Proceedings of the National Academy of Sciences - August 7, 2018 Category: Science Authors: Jakub Otwinowski, David M. McCandlish, Joshua B. Plotkin Tags: PNAS Plus Source Type: research