Diffuse alveolar hemorrhage is most often fatal and is affected by graft source, conditioning regiment toxicity, and engraftment kinetics.

Diffuse alveolar hemorrhage is most often fatal and is affected by graft source, conditioning regiment toxicity, and engraftment kinetics. Haematologica. 2018 Aug 03;: Authors: Keklik F, Alrawi EB, Cao Q, Bejanyan N, Rashidi A, Lazaryan A, Arndt P, Dincer EH, Bachanova V, Warlick ED, MacMillan ML, Arora M, Miller J, Brunstein CG, Weisdorf DJ, Ustun C Abstract Diffuse alveolar hemorrhage after hematopoietic stem cell transplantation is a frequently fatal complication with no standard therapy. Although significant changes in supportive and intensive care measures for hematopoietic stem cell transplantation patients have been made over the past decades, the impact of these changes on the incidence and outcome of patients with diffuse alveolar hemorrhage has not been examined. We analyzed 1228 patients who underwent allogeneic hematopoietic stem cell transplantation between 2008-2015 at the University of Minnesota to study the incidence, risk factors, and outcomes of diffuse alveolar hemorrhage. Diffuse alveolar hemorrhage developed in 5% of allogeneic hematopoietic stem cell transplantation recipients, a median day +30 (range +3 to +168 days) after hematopoietic stem cell transplantation. The incidence of diffuse alveolar hemorrhage was significantly greater in recipients of umbilical cord blood versus peripheral blood or marrow grafts (HR: 2.08, 95%CI: 1.16-3.74), p=0.01. In multivariate analysis, delayed neutrophil engraftment or prim...
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research