Nipah virus – India

As of 17 July 2018, a total of 19 Nipah virus (NiV) cases, including 17 deaths, were reported from Kerala State: 18 of the cases were laboratory-confirmed and the deceased index case was suspected to have NiV but could not be tested. The outbreak was localized to two districts in Kerala State: Kozhikode and Malappuram. No new cases or deaths have been reported since 1 June 2018 and, as of 30 July, human-to-human transmission of NiV has been contained in Kerala State.
Source: WHO Disease Outbreaks - Category: Infectious Diseases Tags: news Source Type: news

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This article provides the groundwork and insights as a value addition toward an India-specific framework of action for response and recovery for Nipah outbreaks in future.
Source: Indian Journal of Public Health - Category: International Medicine & Public Health Authors: Source Type: research
Nipah virus is an emerging pathogenic paramyxovirus responsible for sporadic and isolated outbreaks of severe respiratory and neurologic disease in Southern Asia. As a zoonotic virus, disease can manifest in both animals and human with indigenous fruit bats acting as natural reservoirs of the virus. The effects of viral infection vary from acute respiratory distress to fatal encephalitis. There are currently no approved therapeutics or vaccines against the virus, and growing concerns that this highly pathogenic infection has the potential to cause larger epidemics capable of inflicting significant mortality burden.Like the...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research
Authors: Thulaseedaran NK, Kumar KGS, Kumar J, Geetha P, Jayachandran NV, Kamalasanan CG, Mathew S, Pv S Abstract During May 2018 there occurred an outbreak in Kerala, which started in Soopikkada Village, Changarothu Grama Panchayath in Perambra Taluk, Kozhikode district, of a febrile illness with altered sensorium and ARDS. The diagnosis was made from the second case that it is the dreaded nipah infection. Following that 18 cases tested positive for nipah virus infection of which 2 survived. Also there were four deaths with similar clinical picture but which occurred before the virus was identified. They were cons...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Findings help guide surveillance to prevent disease outbreaks More at https://www.nsf.gov/discoveries/disc_summ.jsp?cntn_id=298814&WT.mc_id=USNSF_1 This is a Research News item.
Source: NSF Discoveries - Category: Science Source Type: research
(Cary Institute of Ecosystem Studies) Since its discovery in 1999, Nipah virus has been reported almost yearly in Southeast Asia, with Bangladesh and India being the hardest hit. In a new study, published today in PLoS Neglected Tropical Diseases, scientists used machine learning to identify bat species with the potential to host Nipah virus, with a focus on India -- the site of a 2018 outbreak. Four new bat species were flagged as surveillance priorities.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
by Raina K. Plowright, Daniel J. Becker, Daniel E. Crowley, Alex D. Washburne, Tao Huang, P. O. Nameer, Emily S. Gurley, Barbara A. Han The 2018 outbreak of Nipah virus in Kerala, India, highlights the need for global surveillance of henipaviruses in bats, which are the reservoir hosts for this and other viruses. Nipah virus, an emerging paramyxovirus in the genusHenipavirus, causes severe disease and stuttering chains of transmission in humans and is considered a potential pandemic threat. In May 2018, an outbreak of Nipah virus began in Kerala,> 1800 km from the sites of previous outbreaks in eastern India in 2001 an...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Authors: Ochani RK, Batra S, Shaikh A, Asad A Abstract The Nipah virus was discovered twenty years ago, and there is considerable information available regarding the specificities surrounding this virus such as transmission, pathogenesis and genome. Belonging to the Henipavirus genus, this virus can cause fever, encephalitis and respiratory disorders. The first cases were reported in Malaysia and Singapore in 1998, when affected individuals presented with severe febrile encephalitis. Since then, much has been identified about this virus. These single-stranded RNA viruses gain entry into target cells via a process k...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
by Neeltje van Doremalen, Teresa Lambe, Sarah Sebastian, Trenton Bushmaker, Robert Fischer, Friederike Feldmann, Elaine Haddock, Michael Letko, Victoria A. Avanzato, Ilona Rissanen, Rachel LaCasse, Dana Scott, Thomas A. Bowden, Sarah Gilbert, Vincent Munster Nipah virus (NiV) is a highly pathogenic re-emerging virus that causes outbreaks in South East Asia. Currently, no approved and licensed vaccine or antivirals exist. Here, we investigated the efficacy of ChAdOx1 NiVB, a simian adenovirus-based vaccine encoding NiV glycoprotein (G) Bangladesh, in Syrian hamsters. Prime-only as well as prime-boost vaccination resulted i...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
India has put more than 300 people under surveillance after a 23-year-old man was diagnosed with the Nipah virus, a rare and often deadly disease.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
Nipah virus is an emerging pathogen in the Paramyxoviridae family. Upon transmission of Nipah virus from its natural reservoir, Pteropus spp. fruit bats, to humans, it causes respiratory and neurological disease with a case-fatality rate about 70%. Human-to-human transmission has been observed during Nipah virus outbreaks in Bangladesh and India. A therapeutic treatment for Nipah virus disease is urgently needed. Here, we tested the efficacy of remdesivir (GS-5734), a broad-acting antiviral nucleotide prodrug, against Nipah virus Bangladesh genotype in African green monkeys. Animals were inoculated with a lethal dose of Ni...
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Reports Source Type: research
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