Heart Monitoring a Must for Breast Cancer Patients on Herceptin
The American Society of Clinical Oncology's 20-year study looked at 49,000 women split into two groups with varying diets
ConclusionsAPBI using 27 Gy in 5 daily fractions achieved acceptable 1-year cosmesis and no grade 2 fibrosis. A preplanned stopping rule of 5% grade 2+ fibrosis was not observed. The trial will continue to the planned target accrual of 274 patients.
A new cancer study that made headlines this week indicates that a low-fat diet may help reduce the risk of dying from breast cancer. The findings of their big, long-term study could have life-changing results. Dr. Tara Narula reports.
CONCLUSIONS The findings of this study suggest the potential for the naturally occurring sesquiterpene lactone santonin in breast cancer treatment and also suggest that it could be developed as a promising anticancer agent. PMID: 31101800 [PubMed - in process]
This study aims at developing algorithms which improve accuracy of computer-aided diagnosis (CADx) for analyzing breast abnormalities on ipsilateral views. The proposed system is a fusion of single and two view systems. Single view approach detects and characterizes suspicious lesions on craniocaudal (CC) and medio-lateral oblique (MLO) view separately using geometric and textural features. Lesions detected on each view are paired with potential lesions on another view. The proposed algorithm computes the correspondence score of each lesion pair. Single view information is fused with two views correspondence score to discr...
CONCLUSION: These data demonstrate that HSYB arrests the MCF-7 cell cycle at the S phase and induces cell apoptosis. Patent US20170246228 indicates that HSYB can be potentially used for the prevention and treatment of human breast cancer. PMID: 31096897 [PubMed - as supplied by publisher]
ConclusionSNB application after PST for breast cancer in node positive patients at presentation is increasing. Pre-operative axillary imaging and tumour biology help identify patients who might be candidates for SNB as a single staging procedure.
Publication date: Available online 17 May 2019Source: Brain, Behavior, and ImmunityAuthor(s): Kyle A. Sullivan, Savannah R. Bever, Daniel B. McKim, Jonathan P. Godbout, John F. Sheridan, Karl Obrietan, Leah M. PyterAbstractCircadian rhythms influence various aspects of biology, including hormonal, immunological, and behavioral processes. These 24-hour oscillations are necessary to optimize cellular functions and to synchronize these processes with the environment. Breast cancer patients and survivors frequently report disruptions in circadian oscillations that adversely affect quality-of-life, including fragmented sleep-wa...
We report new synergistic properties of GO-PEI-GQDs such as stable fluorescence imaging, enhanced photothermal and cytotoxic activity on cancer cells. Composite materials made up of GO and GQDs combining diverse properties help to study 2D-0D heterosystems and improve specific therapeutic systems in theranostics.Graphical abstract
Publication date: Available online 17 May 2019Source: Journal of Molecular StructureAuthor(s): Marta Szumilak, Anna Lichota, Andrzej Olczak, Małgorzata Szczesio, Andrzej StańczakAbstractQuinazoline nucleus is found in many bioactive molecules exhibiting anticancer activity. Herein we report crystallographic investigation, as well as in vitro determination of the biological activity of symmetrical molecules containing two quinazoline systems tethered by various polyamine linkers e.g. 4-bis(3-aminopropyl)piperazine (I), 4,9-dioxa-1,12-dodecanediamine (II), 3,3′-diamino-N-methyldipropylamine (III). Three new crystal s...