Electron-Microscopy-Based Epitope Mapping Defines Specificities of Polyclonal Antibodies Elicited during HIV-1 BG505 Envelope Trimer Immunization

Comprehensive epitope mapping is fundamental to understanding immune responses. Bianchi et  al. applied electron microscopy to study polyclonal antibody responses in HIV-Env-immunized rabbits. Different antibody specificities were identified and followed over time, revealing the source of neutralization, a distinct class of antibodies, and a highly convergent structural evolution of the neutralizing antibodies.

Source: Immunity - August 7, 2018 Category: Allergy & Immunology Authors: Matteo Bianchi, Hannah L. Turner, Bartek Nogal, Christopher A. Cottrell, David Oyen, Matthias Pauthner, Raiza Bastidas, Rebecca Nedellec, Laura E. McCoy, Ian A. Wilson, Dennis R. Burton, Andrew B. Ward, Lars Hangartner Tags: Article Source Type: research