Missed opportunities: Genetic counseling and testing among an ethnically diverse cohort of women with endometrial cancer.

CONCLUSIONS: Many high-risk women do not receive GCR despite a high rate of germline mutations among these women. Improving GCR among high-risk women will lead to more subsequent GT to identify more Lynch syndrome families and prevent additional cancers. Among our ethnically diverse cohort, two women diagnosed with LS had retained MMR protein expression. GCR should be offered to women who possess high-risk characteristics despite normal MMR protein expression.
PMID: 30077346 [PubMed - as supplied by publisher]

Source: Gynecologic Oncology - August 1, 2018 Category: Cancer & Oncology Authors: Lee J, Gubernick LR, Brodsky AL, Fehniger JE, Levine DA, Gerber D, Asgari SA, Cantor A, Martineau JT, Ginsburg OM, Smith JA, Pothuri B Tags: Gynecol Oncol Source Type: research