Retinal Arteriolar Narrowing in Young Adults With Glaucomatous Optic Disc

This study aimed to assess the retinal vessel diameter, as surrogate markers of vascular regulation, in healthy young adults with GOD compared with normal. Materials and Methods: This was a clinic-based case-control study of 54 participants, aged between 18 and 30 years. We included patients with GOD (confirmed with slit-lamp and optical coherence tomography examination having cup-to-disc ratio ≥0.5), intraocular pressure ≤21 mm Hg, no history of hypertension, cardiovascular and kidney disease, anemia, diabetes mellitus, and spherical correction of ≤−1.5 D. Controls were healthy subjects with similar criteria but no sign of GOD. Retinal vessel diameters were measured using semiautomated program [Singapore I Vessel Assessment (SIVA) version 4.0] and expressed as central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent. Results: The mean CRAE was significantly narrower in patients with GOD than controls (110.6±12.16 vs. 118.6±12.17; P=0.019). Central retinal venular equivalent was not significantly different. A CRAE narrower than 107.1 μm was significantly associated with GOD (odds ratio, 8.59; 95% confidence interval, 1.68-43.9; P
Source: Journal of Glaucoma - Category: Opthalmology Tags: Original Studies Source Type: research