Integrated profiling of phenotype and blood transcriptome for stress vulnerability and depression

This study presents an opportunity to understand how multiple psychological traits and underlying molecular mechanisms interact to render individuals vulnerable to depression.
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research

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 Throughout our lives, we are inspired by many people, from our parents to our teachers to celebrities to great thinkers of the past and present. And sometimes, we find ourselves being an inspiration for others. Also, sometimes, this fact surprises us. In this episode, Gabe and Michelle talk about both being inspired by others and how it feels to be an inspiration to others.   SUBSCRIBE &REVIEW “In the right light, all of us are fantastic. In the right, light we all suck.” – Gabe Howard   Highlights From ‘Inspiration’ Episode [00:30] Is Michelle amazing? [3:30] Is Ga...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: A Bipolar, A Schizophrenic, and a Podcast Inspiration & Hope Schizophrenia Success & Achievement Source Type: blogs
DISCUSSION: These results show that ADHD coaggregated with other major psychiatric disorders, specifically schizophrenia, bipolar disorder, major depressive disorder, and ASD, within families. The results suggest that public health officials and psychiatrists should closely monitor and follow the mental health of FDRs of ADHD-diagnosed individuals, such as parents and siblings of children with ADHD. PMID: 31090279 [PubMed - in process]
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
Being hospitalized for any reason is never a fun time, but there are some instances where it can be a harrowing experience. This is especially true for psychiatric patients, who are already in a crisis even before being plunged into the hospital atmosphere, which can overwhelm them. This disconnect between patients and hospital staff has long been an issue. Today’s guest shares some insights on her work to improve this relationship.   Subscribe to Our Show! And Remember to Review Us! About Our Guest Since 2017, Gretchen L. Ramsey, MPS has been the Director of Patient Experience at Geisinger Ho...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General The Psych Central Show Treatment Gabe Howard patient experience Vincent M. Wales Source Type: blogs
Severe mental illnesses (SMI), including major depression, bipolar disorder and schizophrenia, are associated with increased inflammation. Given diet’s role in modulating inflammatory processes, excessive ‘fast-food’ intake, and lack of adequate nutrition, may contribute towards the heightened inflammation observed in SMI. This review assesses the evidence from observational and experimental studies to investigate how diet and nutrition may affect physical and mental health outcomes in SMI through inflammation-related pathways. Cross-sectional studies indicate that individuals with SMI, particularly schiz...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Publication date: Available online 13 May 2019Source: Schizophrenia Research: CognitionAuthor(s): Philip D. Harvey, Alexandra M. Balzer, Raymond J. KotwickiAbstractComputerized cognitive training (CCT) interventions are increasing in their use in outpatient mental health settings. These interventions have demonstrated efficacy for improving functional outcomes when combined with rehabilitation interventions. It has recently been suggested that patients with more cognitive impairment have a greater therapeutic response and that reduced engagement in training can identify cases who manifest low levels of benefit from treatme...
Source: Schizophrenia Research: Cognition - Category: Psychiatry Source Type: research
Visual defects are well documented in psychiatric disorders such as schizophrenia, bipolar disorder and major depressive disorder. One of the most replicated alteration in patients is decreased electroretinographic (ERG) responses. We previously showed a diminished rod b-wave amplitude in a small sample of children born to an affected parent (H ébert 2010). The fact that an ERG anomaly found in patients would also be observed in children at high genetic risk (HR) suggests a neurodevelopmental origin.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research
Computerized device uses (CDU; e.g., playing computer games (CompGaming), mobile phone use (minutes/week for the last three months (PhoneUse) and total usage years), hands-free/speakerphone device use). Epidemiological associations between CDUs and psychiatric disorders are frequently reported; the biological mechanisms underlying these observations remain unknown. We investigated genetic overlap and causality between CDUs and psychiatric disorders (attention deficit hyperactivity disorder (ADHD), schizophrenia (SCZ), autism spectrum disorder, major depressive disorder, alcohol dependence, bipolar disorder, anorexia nervos...
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research
The 2nd- to 4th-finger ratio (2D:4D) has been proposed as a potential indicator of greater androgen exposure during fetal development. While smaller digit ratios, suggestive of stronger perinatal androgen action, have been associated with male-linked disorders (e.g., autism), problematic video gaming behavior, larger digit ratios, suggestive of weaker perinatal androgen action, have been associated with depression, schizophrenia, and eating disorders. We investigated association between the (2D:4D) and bipolar disorder.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research
Mood disorders such as major depressive and bipolar disorders, along with posttraumatic stress disorder (PTSD), schizophrenia (SZ) and other psychotic disorders constitute serious mental illnesses (SMI), leading to inpatient psychiatric care for adults. These disorders are heterogeneous with variable phenotypes, which make them challenging to diagnose prior to the onset of severe symptoms, and difficult to treat effectively. Risk factors increasing the rate of hospitalization in SMI are largely unknown, but likely involve a combination of genetic, environmental, and socio-behavioral factors.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research
Traditional genetic studies have failed to find individual genes of large effect size in major psychiatric disorders. Using network-based approaches, we aimed to (1) identify transcription factors acting as potential master regulators (MRs) in Bipolar Disorder (BD), Schizophrenia (SZ) and Major Depressive Disorder (MDD); (2) Investigate the activation/repression patterns of these MRs, as well as the enriched biological processes in each disorder, to characterize diseases ’ transcriptional phenotypes.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research
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