Dynamics of DDB2-DDB1 complex under different naturally-occurring mutants in Xeroderma Pigmentosum disease

ConclusionsThe data gathered throughout the analyses helps enlighten the structural basis for how naturally occurring mutations found in XPE patients impact on DDB2 and DDB1 function.General significanceOur data influence not only on the knowledge of XP but on the DNA repair mechanisms of NER itself.
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research