Radiation Induced Cerebral Microbleeds in Pediatric Patients with Brain Tumors Treated with Proton Radiotherapy

This study investigates radiation-induced cerebral microbleeds (CMBs) in pediatric patients with primary brain tumors treated with proton radiotherapy. This complication of radiotherapy has not been significantly studied following proton radiotherapy in the pediatric patient population, particularly with regards to timing, incidence and associated risk factors. CMBs have been associated with decreased neurocognitive function indicating the potential clinical significance. This research establishes an estimate for the timing and incidence of CMBs, evaluates how CMBs accrue over time, investigates risk factors associated with development of CMBs, and allows for a comparison between photon and proton radiotherapy.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Source Type: research