Increased neutrophil-lymphocyte ratios in depressive adolescents is correlated with the severity of depression.

A growing body of evidence has emphasized the role of low-grade inflammation in the underlying pathophysiology of major depressive disorder (MDD) (Dowlati et al., 2010; Kim et al., 2014). Contrary to previous belief, it is well documented that the immune system and brain are in complex bidirectional interaction in health and disease (Bilbo and Schwarz, 2012; Yirmiya and Goshen, 2011). Studies suggest that immune mediators may affect neurotransmission, neural activity and neuroendocrine pathways leading to MDD (Capuron and Miller, 2011; Dantzer et al., 2011; Leonard and Maes, 2012; Kiecolt-Glaser et al., 2015).

Source: Psychiatry Research - August 6, 2018 Category: Psychiatry Authors: Gonca Özyurt, Nagihan Cevher Binici Source Type: research