Doxorubicin disrupts the immune system to cause heart toxicity
(University of Alabama at Birmingham) Doxorubicin is a chemotherapy drug used in ovarian, bladder, lung, thyroid and stomach cancers, but it carries a harmful side effect. The drug causes a dose-dependent heart toxicity that can lead to congestive heart failure. Researchers have found an important contributor to that heart pathology -- disruption of the metabolism that controls immune responses in the spleen and heart. This dysregulated immunometabolism impairs resolution of inflammation, and chronic, non-resolving inflammation leads to advanced heart failure.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
More News: Biology | Bladder Cancer | Cancer | Cancer & Oncology | Cardiology | Chemotherapy | Congestive Heart Failure | Gastric (Stomach) Cancer | Heart | Heart Failure | Ovarian Cancer | Ovaries | Pathology | Thyroid | Thyroid Cancer | Toxicology