Pedunculated Upper Esophageal Adenocarcinoma in Lynch Syndrome

An 84-year-old woman was referred to our hospital for an esophageal polypoid lesion. Endoscopy showed a pedunculated polyp (Figure A, left) and heterotopic gastric mucosa (HGM) (Figure  A, right, arrow) in the upper esophagus, and histologic examination of the biopsy specimen showed adenocarcinoma (Figure B). Because magnetic resonance imaging showed metastatic brain tumors, polypectomy was not performed and the patient died 3 months later.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Image of the Month Source Type: research

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Authors: Dong Y, Li G Abstract Nonalcoholic fatty liver disease (NAFLD) is one of the most common forms of chronic liver disease in developed countries and is associated with type 2 diabetes mellitus, obesity, hypertension, dyslipidemia, and metabolic syndrome. It is defined as steatosis in over 5% of hepatocytes. The disease spectrum of NAFLD ranges from simple fatty liver to nonalcoholic steatohepatitis, liver fibrosis, even hepatic cirrhosis. The disease affects various extra-hepatic systems such as the cardiovascular system and urinary system. Heart-related disease is identified as the leading cause of mor...
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
Magnetic resonance imaging (MRI) could be a successful technology for understanding the severity ofmeningioma, according to a  studyrecently published inClinical Radiology. Determining if meningioma is high grade or low grade can help physicians decide how the tumor should be managed. Researchers from the American University Beirut Medical Center ventured to find out if MRI could help identify the meningioma grade before it ’s removed from the patient, making surgery easier and safer. The researchers analyzed scans of 71 patients who had undergone surgeries to remove intracranial meningiomas at America...
Source: radRounds - Category: Radiology Authors: Source Type: blogs
ConclusionMR Esophagography might become a non-invasive, non-irradiating technique of choice following diagnostic esophagogastroduodenoscopy for the assessment of esophageal diseases.
Source: European Journal of Radiology - Category: Radiology Source Type: research
Conclusions: There are several ongoing efforts to use novel ablative therapies directed towards the brain. The recent development of techniques that allow for precise targeting, accurate delivery of thermal doses and real-time visualization of induced tissue damage during the procedure have resulted in novel techniques for cerebral ablation such as magnetic resonance-guided focused ultrasound or laser interstitial thermal therapy. However, older techniques such as radiofrequency thermal ablation or stereotactic radiosurgery still have a pivotal role in the management of a variety of neurological disorders. PMID: 315371...
Source: International Journal of Hyperthermia - Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research
Authors: Gawlinska K, Gawlinski D, Przegalinski E, Filip M Abstract A balanced maternal diet is necessary for the proper health and development of offspring. Recent clinical and preclinical studies have strongly indicated that maternal exposure to a high-fat diet (HFD) can have an irreversible impact on the structure and function of the offspring's brain and affect the immune system, which may predispose the offspring to brain disorders, including depression. The irisin/brain-derived neurotrophic factor (BDNF) axis is a pathway that influences several neurobehavioral mechanisms involved in the pathogenesis of menta...
Source: Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research
Publication date: Available online 20 September 2019Source: Seminars in Cancer BiologyAuthor(s): Trista K. Hinz, Lynn E. HeasleyAbstractMalignant pleural mesothelioma (MPM) is a rare, yet lethal asbestos-induced cancer and despite marked efforts to reduce occupational exposure, the incidence has not yet significantly declined. Since 2003, combined treatment with a platinum-based agent and pemetrexed has been the first-line therapy and no effective or approved second-line treatments have emerged. The seemingly slow advance in developing new MPM treatments does not appear to be related to a low level of clinical and pre-clin...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
In this study, we investigated the development of the MNS by examining the correlations in spontaneous fluctuations of the functional magnetic resonance imaging (fMRI) blood oxygen level-dependent (BOLD) signal in healthy, 3–5-year-old preschool children (n = 30, 15 in each group). Using a ROI-based (inferior frontal gyrus) functional connectivity analysis, we identified a right lateralized MNS during rest in both groups with a positive correlation between the inferior frontal gyrus and inferior parietal lobule. A significant increase in the functional connectivity of the MNS was observed in the older group. Our ...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
ConclusionOur case shows that diffuse midline glioma is a CNS tumor not limited to young population but occurring also in middle aged patients with an insidious pattern. We therefore recommend to perform biopsy at very early stages in patients with atypical brainstem lesions.
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
I was out of work for 31 days, from August 16 until September 17. The reason is because I had surgery on my left knee, an arthroscopy of the medial meniscus. It got damaged somehow; the cause is unknown to me. It started becoming problematic sometime around Christmas 2018, but I didn’t really pay much attention to it. I figured it had to be something fairly minor which would resolve itself. However, it didn’t. And ultimately it led to my being evaluated by an orthopedic surgeon, having to get X-Rays and Magnetic Resonance Imaging on my knee, and finally having the surgical procedure performed to fix the problem...
Source: Qui Interrogat - Category: Nursing Authors: Tags: Uncategorized Source Type: blogs
Authors: Beita AKV, Whayne TF Abstract This review is directed at increasing awareness of two diverse rare upper gastrointestinal problems that occur at opposite ends of the age spectrum and are difficult to diagnose and treat. The superior mesenteric artery syndrome (SMAS) likely involves a young patient, especially female, and is especially associated with rapid weight loss, resulting in relative strangulation of the duodenum by a narrowing of the angle between the superior mesenteric artery (SMA) and the aorta. On the other hand, atherosclerosis of the SMA is associated most likely with postprandial upper intest...
Source: Cardiovascular and Hematological Agents in Medicinal Chemistry - Category: Cardiology Tags: Cardiovasc Hematol Agents Med Chem Source Type: research
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