Pilot Study: Regional Changes in Brain 18F-FDG Uptake After Prophylactic Cranial Irradiation and Chemotherapy in small cell lung cancer May Reflect Functional Changes.

Conclusion: Significantly more patients had unilateral rather than bilateral regional differences (both increases and decreases) in 18F-FDG uptake in the brain pre-and post PCI. This suggests that differences in unilateral distribution are related to functional changes, since direct toxicity alone from PCI and chemotherapy would be symmetric. The frontal region was the most commonly affected, suggesting a potential contributing etiology for cognitive impairment and decreased executive function after therapy. PMID: 30076247 [PubMed - as supplied by publisher]
Source: Journal of Nuclear Medicine Technology - Category: Nuclear Medicine Tags: J Nucl Med Technol Source Type: research