FOXD3 acts as a repressor of the mitochondrial S-adenosylmethionine carrier (SLC25A26) gene expression in cancer cells.

In this study we show that a silencer activity is present in the region from -756 bp to -504 bp, which specifically binds a protein present in Caski cells nuclear extracts. By in silico analysis, EMSA, ChIP, overexpressing and silencing experiments this protein was identified as FOXD3 which acts as a repressor of SLC25A26 expression. Interestingly, the repressor activity of FOXD3 is completely abolished by treating Caski cells with folate via a mechanism that involves methylation of FOXD3 gene promoter. This finding could have important impact in cancer cells where SLC25A26 is downregulated. Finally, the DPE and INR putative sites were also identified. PMID: 30076902 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30076902?dopt=Abstract

Source: Biochimie - August 1, 2018 Category: Biochemistry Authors: Antonia C, Alessio M, Ferdinando P, Vito I Tags: Biochimie Source Type: research