Intra-thoracic adiposity is associated with impaired contractile function in patients with coronary artery disease: a cardiovascular magnetic resonance imaging study

AbstractThe influence of visceral adiposity on left ventricular remodeling following coronary artery disease (CAD)-related events has not been examined to date. Using magnetic resonance imaging (MRI) we explored intra-thoracic fat volume (ITFV) and strain-based markers of adverse remodeling in patients with CAD. Forty-seven patients with known CAD (25 with prior MI, 22 without prior MI) were studied. ITFV was quantified using previously validated imaging techniques. Myocardial strain was derived from cine MRI using a validated 3D feature-tracking (FT) software. Segmental LGE quantification was performed and was used to incrementally constrain strain analyses to non-infarcted (i.e. remote) segments. Remote myocardial strain was compared to the non-MI control cohort and was explored for associations with ITFV. Mean age was 57  ± 13 years with a mean BMI of 30.0 ± 6.2 kg/m2 (range 20.3 –38.4 kg/m2). Patients with versus without prior MI had similar demographics and BMI (29.4  ± 4.4 vs. 30.4 ± 7.9 kg/m2,p = 0.62). Patients with prior MI had lower mean peak strain than non-MI patients (p = 0.02), consistent with remote tissue contractile dysfunction. Inverse associations were identified between ITFV and mean peak strain in both the MI group (circumferential: r = 0.43,p = 0.03; radial: − 0.41,p = 0.04; minimum principal: r = 0.41,p = 0.04; maximum principal: r = − 0.43,p = 0.03) and non-MI group (circumferential:...
Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research