Structural basis of phospholipase A2-like myotoxin inhibition by chicoric acid, a novel potent inhibitor of ophidian toxins

ConclusionsCA prevents the myotoxic activity of the toxin, preventing its activation by simultaneous binding with two critical regions.General significanceCA is a potential myotoxic inhibitor to other PLA2-like proteins and a possible candidate to complement serum therapy.

Source: Biochimica et Biophysica Acta (BBA) General Subjects - August 4, 2018 Category: Biochemistry Source Type: research