IL-13 is produced by tumor cells in breast implant –associated anaplastic large cell lymphoma: implications for pathogenesis

More than 500 women worldwide have developed a CD30+ T-cell lymphoma around breast implants, strongly suggesting a cause-and-effect relationship, and designated as breast implant –associated anaplastic large cell lymphoma (BIA-ALCL). The mechanism of lymphomagenesis is unknown. Recently, a bacterial biofilm containing gram-negative bacilli was discovered on the surface of breast implants associated with ALCL. We and others have described overexpression of the proto-oncogen e JUNB and mutations of JAK1/2, TP53 and STAT3 in BIA-ALCL.

Source: Human Pathology - April 21, 2018 Category: Pathology Authors: Marshall E. Kadin, John Morgan, Haiying Xu, Alan L. Epstein, David Sieber, Bradley A. Hubbard, William P. Adams, Carlos E. Bacchi, Joao C.S. Goes, Mark W. Clemens, L. Jeffrey Medeiros, Roberto N. Miranda Tags: Original contribution Source Type: research