Contributions of RecA and RecBCD DNA repair pathways to the oxidative stress response and sensitivity of Acinetobacter baumannii to antibiotics

Reactive oxygen species (ROS) including superoxide anion radical ( •O2−), hydrogen peroxide (H2O2) and hydroxyl radical (•OH) are ubiquitous oxygen derivatives that have emerged as important players in antibiotic-mediated bacterial lethality [1–4]. They are inevitable toxic by-products of aerobic respiratory processes of living organisms [5], which are rest rained by bacterial ROS defense mechanisms such as superoxide dismutase, catalase, peroxidases and the glutathione system. These noxious species damage Fe-S clusters, releasing Fe2+ to catalyse the conversion of H2O2 to •OH via Fenton reaction [6,7].

Source: International Journal of Antimicrobial Agents - August 3, 2018 Category: Drugs & Pharmacology Authors: T.O. Ajiboye, E. Skiebe, G. Wilharm Source Type: research