The effect of dexmedetomidine on inflammatory inhibition and microglial polarization in BV-2 cells.

DISCUSSION: Our results indicated that Dex promotes microglia from the M1 phenotype to the M2 phenotype. Therefore, Dex may be a potential novel therapeutic drug for treating brain inflammation-associated diseases not only because of its anti-inflammatory property but also because it can remodel M1 phenotype microglia to M2 phenotype microglia. PMID: 30071186 [PubMed - as supplied by publisher]
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research