The characteristics of a preservative-free contact lens care solution on lysozyme adsorption and interfacial friction behavior

Publication date: Available online 3 August 2018Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Chen-Ying Su, Chi-Chun Lai, Lung-Kun Yeh, Kuan-Yi Li, Bo-Wu Shih, Ching-Li Tseng, Hsu-Wei FangAbstractThe population of soft contact lens wearers is increasing, thus the issues of feeling comfortable and contact lens-induced clinical symptoms are concerned. Both lysozyme deposition and mechanical friction among contact lens and the eye can induce discomfort and eye conditions. Therefore, we characterized our developed preservative-free contact lens care solution on lysozyme adsorption and lubrication. Two distinct lens materials were washed with the care solution after being soaked in lysozyme, as well as were rubbed against the glass in the presence of lysozyme and the care solution for measuring the friction coefficient. Our results demonstrated that the preservative-free contact lens care solution can be applied as a potential lubricant for a specific type of soft contact lenses.Graphic abstractWhen a contact lens is in contact with an eye, tear protein such as lysozyme starts to be accumulated on the lens. The friction between the eyelid and the lens often results in discomfort of the wearer and the conformational changes of lysozyme. Our study demonstrates that lysozyme deposition increases on both ionic and nonionic contact lenses, but only the friction coefficient is increased on the nonionic contact lens due to the conformational change. By cleaning the lens with o...
Source: Colloids and Surfaces B: Biointerfaces - Category: Biochemistry Source Type: research
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