Alzheimer's as the Endpoint of a Life-Long Burden of Infectious Disease

The long years of failure in Alzheimer's research, in which trial after trial of immunotherapies targeting amyloid-β produced no meaningful benefits in Alzheimer's patients, has sown the seeds of change in the research community. In the past couple of years, promising human data for amyloid-β clearance has finally arrived, but the damage is done. The amyloid hypothesis for Alzheimer's disease is now challenged, and alternative theories are thriving. One of particular note is built upon the point that generation of amyloid in the brain appears to be a defensive mechanism of the innate immune system, and thus its proponents see Alzheimer's as the end result of persistent infection, such as by herpesviruses or the bacteria of lyme disease. In this view of the world, Alzheimer's is just another of the many unpleasant late consequences of a high disease burden sustained throughout life. We are, after all, far better off than our recent ancestors thanks to increased control over infectious disease. Chronic inflammation and other consequences of the burden of parasitism and infectious disease resulted in earlier frailty in later life and shortened life expectancy until the advent of widespread antibiotics and other, similarly influential 20th century medical advances. Nonetheless, many infectious agents remain uncontrolled or poorly controlled - the ones whose effects are sufficiently subtle and slow to have evaded early notice. Numerous herpesviruses have few to no...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs

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ConclusionsThe trial demonstrated a favorable safety profile of the SQ HDM SLIT tablet in Japanese adult patients with AA. The treatment appeared to be efficacious in patients requiring rescue medication (ie, short-acting β2-agonist) at baseline in the efficacy assessment using asthma exacerbation during inhaled corticosteroid reduction (JapicCTI number 121847).
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
Publication date: Available online 5 October 2019Source: NeuroImageAuthor(s): AmanPreet Badhwar, Yannik Collin-Verreault, Pierre Orban, Sebastian Urchs, Isabelle Chouinard, Jacob Vogel, Olivier Potvin, Simon Duchesne, Pierre BellecAbstractStudies using resting-state functional magnetic resonance imaging (rsfMRI) are increasingly collecting data at multiple sites in order to speed up recruitment or increase sample size. The main objective of this study was to assess the long-term consistency of rsfMRI connectivity maps derived at multiple sites and vendors using the Canadian Dementia Imaging Protocol (CDIP, www.cdip-pcid.ca...
Source: NeuroImage - Category: Neuroscience Source Type: research
Publication date: Available online 20 September 2019Source: NeuroImageAuthor(s): Laurent Chauvin, Kuldeep Kumar, Christian Wachinger, Marc Vangel, Jacques de Guise, Christian Desrosiers, William Wells, Matthew Toews, for the Alzheimer's Disease Neuroimaging InitiativeAbstractNeuroimaging studies typically adopt a common feature space for all data, which may obscure aspects of neuroanatomy only observable in subsets of a population, e.g. cortical folding patterns unique to individuals or shared by close relatives. Here, we propose to model individual variability using a distinctive keypoint signature: a set of unique, local...
Source: NeuroImage - Category: Neuroscience Source Type: research
Conclusions: Hungarian GPs were aware of the benefits of early recognition, but the shortage of consultation time in primary care was found to be a major constraint on efficient case-finding. PMID: 31601132 [PubMed - as supplied by publisher]
Source: European Journal of General Practice - Category: Primary Care Tags: Eur J Gen Pract Source Type: research
In conclusion, a polypharmacology approach of combining established, prolongevity drug inhibitors of specific nodes may be the most effective way to target the nutrient-sensing network to improve late-life health. Deletion of p38α in Neurons Slows Neural Stem Cell Decline and Loss of Cognitive Function in Mice https://www.fightaging.org/archives/2019/10/deletion-of-p38%ce%b1-in-neurons-slows-neural-stem-cell-decline-and-loss-of-cognitive-function-in-mice/ Researchers here provide evidence for p38α to be involved in the regulation of diminished neural stem cell activity with age. It is thought...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Those who could benefit from activity to avoid disabilities are told not to get up on their own: “They’re not letting me get up out of bed.”
Source: Washington Post: To Your Health - Category: Consumer Health News Authors: Source Type: news
Authors: Babor TF, Ferreira-Borges C PMID: 31603745 [PubMed - in process]
Source: Journal of Studies on Alcohol and Drugs - Category: Addiction Tags: J Stud Alcohol Drugs Source Type: research
We examined the influence of enrollment factors demonstrated to differ by race on incident mild cognitive impairment and dementia using Alzheimer's Disease Center data. METHODS: Differences in rates of incident impairment between non-Latino Whites and Blacks (n = 12,242) were examined with age-at-progression survival models. Models included race, sex, education, source of recruitment, health factors, and family history of dementia. RESULTS: No significant race differences in progression were observed in cognitively unimpaired participants. In those with mild cognitive impairment at baseline, Whites eviden...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Publication date: Available online 11 October 2019Source: Life SciencesAuthor(s): Qinqing Li, Feifei Xu, Qi Zhang, Xiaoqing Li, Meitong Guo, Yiming Zhang, Zilin Wang, Jie Wang, Jiaqi Zhao, Yajuan Tian, Zhao Zhang, Shifeng Chu, Wenbin HeAbstractAimsLearning and memory impairment is a common symptom in the early stages of various types of dementia. It is likely to reduce the incidence of dementia with correct intervention. α-Asarone is the main bioactive substance isolated from Acorus tatarinowii Schott and has been proven to improve memory dysfunction; however, at present, the specific underlying mechanism is poorly u...
Source: Life Sciences - Category: Biology Source Type: research
AbstractNatural killer (NK) cells are innate immune lymphocytes which express an array of activating and inhibitory receptors. These receptors bind a large spectrum of ligands, which are expressed on stressed, malignantly transformed or virally infected cells, as well as on bacterial, fungal, and parasitic pathogens. The decision on whether or not to kill the target is based on the integration of activating and inhibitory signals sent downstream from NK cell receptors. One of the most prominent NK cell activating receptor families is the family of natural cytotoxicity receptors (NCRs) which includes NKp30, NKp44, and NKp46...
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research
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