Spigelman Stage IV Duodenal Polyposis Does Not Precede a Majority of Duodenal Cancer Cases in Patients with Familial Adenomatous Polyposis

The greatest known risk factor for duodenal cancer in FAP is Spigelman Stage (SS) IV duodenal polyposis. Endoscopic surveillance is recommended in FAP patients with SS 0-IV and prophylactic duodenectomy should be considered in SS IV. Cancer occurs in patients without SS IV polyposis. We assessed the relationship of SS and other factors with duodenal cancer in FAP.

Source: Gastrointestinal Endoscopy - August 3, 2018 Category: Gastroenterology Authors: Sushrut S. Thiruvengadam, Rocio Lopez, Margaret O ’Malley, Lisa LaGuardia, James M. Church, Matthew Kalady, R. Matthew Walsh, Carol A. Burke Source Type: research