Molecules, Vol. 23, Pages 1943: pH Stability and Antioxidant Power of CycloDOPA and Its Derivatives

Molecules, Vol. 23, Pages 1943: pH Stability and Antioxidant Power of CycloDOPA and Its Derivatives Molecules doi: 10.3390/molecules23081943 Authors: Shiori Nakagawa Zetryana Puteri Tachrim Natsumi Kurokawa Fumina Ohashi Yasuko Sakihama Takeyuki Suzuki Yasuyuki Hashidoko Makoto Hashimoto CycloDOPA (leukodopachrome), a well known metabolite of tyrosine, is a precursor of melanine in mammalian organisms and of the pigment betalain in plants. However, the isolation of cycloDOPA from natural sources has not been widely reported. In the present work, the stabilities of cycloDOPA and cycloDOPA methyl ester at various pH levels were studied. Both compounds were stable under acidic conditions. By contrast, both compounds were unstable when the pH was shifted from neutral to basic to form indole derivatives as major products. Based on the pH stability, cycloDOPA and its derivatives were subjected to the DPPH radical scavenging assay for the first time.
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
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