Molecules, Vol. 23, Pages 1943: pH Stability and Antioxidant Power of CycloDOPA and Its Derivatives
Molecules, Vol. 23, Pages 1943: pH Stability and Antioxidant Power of CycloDOPA and Its Derivatives
Molecules doi: 10.3390/molecules23081943
Authors:
Shiori Nakagawa
Zetryana Puteri Tachrim
Natsumi Kurokawa
Fumina Ohashi
Yasuko Sakihama
Takeyuki Suzuki
Yasuyuki Hashidoko
Makoto Hashimoto
CycloDOPA (leukodopachrome), a well known metabolite of tyrosine, is a precursor of melanine in mammalian organisms and of the pigment betalain in plants. However, the isolation of cycloDOPA from natural sources has not been widely reported. In the present work, the stabilities of cycloDOPA and cycloDOPA methyl ester at various pH levels were studied. Both compounds were stable under acidic conditions. By contrast, both compounds were unstable when the pH was shifted from neutral to basic to form indole derivatives as major products. Based on the pH stability, cycloDOPA and its derivatives were subjected to the DPPH radical scavenging assay for the first time.
Source: Molecules - Category: Chemistry Authors: Shiori Nakagawa Zetryana Puteri Tachrim Natsumi Kurokawa Fumina Ohashi Yasuko Sakihama Takeyuki Suzuki Yasuyuki Hashidoko Makoto Hashimoto Tags: Article Source Type: research
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