Prognostic Value of Urinary Calprotectin, NGAL and KIM-1 in Chronic Kidney Disease

Conclusion: In contrast to the traditional biomarker “albuminuria”, neither the inflammatory biomarker calprotectin, nor the tubular biomarkers NGAL and KIM-1, provide robust prognostic information on the loss or renal function in a heterogeneous CKD population. All of them, however, are candidate prognostic biomarkers in primarily inflammatory re nal diseases.Kidney Blood Press Res 2018;43:1255 –1262
Source: Kidney and Blood Pressure Research - Category: Urology & Nephrology Source Type: research

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Conclusions:In a middle-aged population-based cohort, the prevalence of a RERA index≥ 5 events/h was low (3.8%) and was not associated with negative clinical outcomes when using the currently recommended scoring criteria of the American Academy of Sleep Medicine.Citation:Ogna A, Tobback N, Andries D, Preisig M, Vollenweider P, Waeber G, Marques-Vidal P, Rubio JH, Heinzer R. Prevalence and clinical significance of respiratory effort-related arousals in the general population.J Clin Sleep Med. 2018;14(8):1339–1345.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
We describe an 8-year-old male with a pathogenicUNC80 mutation, intellectual disability, hypotonia and epilepsy with severe central sleep apnea (213.5 events/h) on polysomnography (PSG). We also describe a 20-month-old female with aKCNJ11 mutation, neonatal diabetes and developmental delay who had severe central sleep apnea (131.1 events/h). Both patients had irregular respiratory patterns during sleep and wakefulness and were placed on empiric bilevel positive airway pressure therapy, which was well tolerated with resolution of abnormal respiratory control and hypercapnia. Patients withUNC80 andKCNJ11 gene mutations may h...
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
In conclusion, we have demonstrated AE has benefits to regulate DPP-4 and GLP-1R, to reduce oxidative stress and renal fibrosis, with resultant to improve renal function and prevent diabetic renal damage. Taken together, F2 could be more promising to be developed as adjuvant for diabetic nephropathy.Graphical abstract
Source: Journal of Food and Drug Analysis - Category: Food Science Source Type: research
Capillary Biomedical Inc. has raised $2.9 million in a seed funding that will help it bring its diabetes management technology to market. The round was led by the Cove Fund with participation by a syndicate of Angel Groups and accredited investors. Irvine, California-based Capillary Biomedical said it plans to use the funds for clinical studies to support regulatory clearance and preparation for commercial launch in 2019. CapBio i s developing a novel infusion set for use with insulin pumps for…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Publication date: Available online 14 August 2018Source: Life SciencesAuthor(s): Leônidas Graças Mendes-Junior, Leandro Ceotto Freitas-Lima, Janaína Ribeiro Oliveira, Marcos B. Melo, Carlos Eduardo Mendes D'Angelis, Jonh David Feltenberger, Igor Viana Brandi, Bruna Mara Aparecida Carvalho, André Luiz Sena Guimarães, Alfredo Maurício Batista De Paula, Carlos Eduardo Mendes D'Angelis, Maria José Campagnole-Santos, Robson Augusto Souza Santos, Valdir Andrade Braga, Sérgio Henrique Sousa SantosAbstractDiabetic cardiomyopathy (DC) describes diabetes-associated changes in th...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 14 August 2018Source: Journal of Arthroscopy and Joint SurgeryAuthor(s): Ramneek Mahajan, Yugal Karkhur, V. Anil, Abhimanyu Kakralia
Source: Journal of Arthroscopy and Joint Surgery - Category: Orthopaedics Source Type: research
Sep 11, 2018. . Sponsored by U.S. Department of Veterans Affairs
Source: Rural events via the Rural Assistance Center - Category: Rural Health Source Type: events
Authors: Glissen Brown JR, Singh P Abstract Coeliac disease (CD) develops in genetically susceptible individuals who, in response to unclear environmental triggers, develop an immune response triggered by gluten ingestion. It is now recognised as a global disease affecting about 0.7% of the world's population. The clinical presentation ranges from malabsorption to asymptomatic individuals diagnosed by screening high-risk groups. Diagnosis requires the demonstration of small intestinal villous atrophy in the presence of circulating coeliac auto-antibodies and/or an unequivocal response to a gluten-free diet (GFD). R...
Source: Paediatrics and international child health - Category: Pediatrics Tags: Paediatr Int Child Health Source Type: research
The UK Court of Appeal decision that will soon allow Dr Hadiza Bawa-Garba to return to work was met with relief by most medical societies there; the overwhelming sentiment was'lessons must be learned. 'Medscape Medical News
Source: Medscape Diabetes Headlines - Category: Endocrinology Tags: Pediatrics News Source Type: news
More insight into the eye as a'window into the brain'comes from a study linking glaucoma, age-related macular degeneration, and diabetic retinopathy to a higher risk for Alzheimer's disease.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news
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