Omega-3 fatty acids for mood disorders

Omega-3 fatty acids are found primarily in fish oil and certain marine algae. Because depression appears less common in nations where people eat large amounts of fish, scientists have investigated whether fish oils may prevent and/or treat depression and other mood disorders. Two omega-3 fatty acids — eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) — are thought to have the most potential to benefit people with mood disorders. How might omega-3s improve depression? Different mechanisms of action have been proposed. For example, omega-3s can easily travel through the brain cell membrane and interact with mood-related molecules inside the brain. They also have anti-inflammatory actions that may help relieve depression. More than 30 clinical trials have tested different omega-3 preparations in people with depression. Most studies have used omega-3s as add-on therapy for people who are taking prescription antidepressants with limited or no benefit. Fewer studies have examined omega-3 therapy alone. Clinical trials typically use EPA alone or a combination of EPA plus DHA, at doses from 0.5 to 1 gram per day to 6 to 10 grams per day. To give some perspective, 1 gram per day would correspond to eating three salmon meals per week. Meta-analyses (research that combines and analyzes results of multiple studies) generally suggest that the omega-3s are effective, but the findings are not unanimous because of variability between doses, ratios of EPA to DHA, and othe...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Anxiety and Depression Behavioral Health Drugs and Supplements Mental Health Source Type: blogs

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Authors: Dhamane AD, Baker CL, Rajpura J, Mardekian J, Dina O, Russ C, Rosenblatt L, Lingohr-Smith M, Lin J Abstract Objective: To compare the risk of hospitalization and costs associated with major bleeding (MB) or stroke/systemic embolism (SE) among elderly patients with nonvalvular atrial fibrillation (NVAF) who initiated apixaban then switched to another oral anticoagulant (OAC) vs. those who continued with apixaban treatment. Methods: NVAF patients (≥65 years) initiating apixaban were identified from the Humana database (1/1/2013-9/30/2017) and grouped into Switcher and Continuer cohorts. For Switchers, the...
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
This study investigated what types of classroom anxiety were related to student performance in the course and persistence in the major. Students in introductory biology classes self-reported their general class, test, communication, and social anxiety; perceived course difficulty; intention to stay in the major; and demographic variables. Final course grades were acquired from instructors. An increase in perception of course difficulty from the beginning to the end of the semester was significantly associated with lower final course grades (N = 337), particularly for females, non-Caucasians, and students who took fewer Adv...
Source: CBE Life Sciences Education - Category: Cytology Authors: Tags: CBE Life Sci Educ Source Type: research
Publication date: July 2019Source: Fish &Shellfish Immunology, Volume 90Author(s):
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: July 2019Source: Fish &Shellfish Immunology, Volume 90Author(s):
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
In conclusion, this study confirms the presence of neuroendocrine-immune regulatory system in marine invertebrates, which contributes to understand the complexity of oyster immune defense system.
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: Available online 24 May 2019Source: Fish &Shellfish ImmunologyAuthor(s): Hongxing Liu, Ting Ye, Tan Kar Soon, Hongkuan Zhang, Dewei Cheng, Shengkang Li, Hongyu Ma, Huaiping ZhengAbstractStocking density is a crucial factor in shellfish aquaculture that affects overall growth performance and health status. Present study analyzes the effects of stocking densities on growth, survival and hemolymph immune status of noble scallop Chlamys nobilis. The scallops with the same size were separately placed in the lantern cages (10 layers per cage) using high stocking density (500 scallops per cage) and low stock...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: Available online 24 May 2019Source: Fish &Shellfish ImmunologyAuthor(s): Ruiqiang Tang, Lingmin Zhao, Xiaojin Xu, Lixing Huang, Yingxue Qin, Yongquan Su, Qingpi YanAbstractAs an important pathogen in aquaculture, Pseudomonas plecoglossicida has caused heavy losses. The expression of an ABC transporter gene-L321_23611 of P. plecoglossicida at 18 °C was found significant higher than those at 28 °C by RNA-seq and qRT-PCR. RNAi significantly reduced the content of L321_23611 mRNA in P. plecoglossicida with a maximal decrease of 89.2%. Compared with the wild type strain, the infection of L321_2...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
In this study, Crassostrea angulata with different levels of Cu and Zn were obtained through metal exposure or selective breeding. Both in vivo and in vitro experiments showed that oysters accumulating more Cu/Zn exhibited stronger antibacterial abilities. Vibrio harveyi infection significantly promoted the metal redistribution in oysters: Cu and Zn concentrations decreased in the mantle, but increased in the plasma and hemocytes. This redistribution was accompanied by changes in the expression levels of Cu and Zn transporter genes (CTR1, ATP7A, ZIP1, and ZNT2), suggesting that the Cu/Zn burst observed in the hemocytes was...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
Publication date: Available online 23 May 2019Source: Fish &Shellfish ImmunologyAuthor(s): Ce Ji, Xinya Guo, Jianfeng Ren, Yao Zu, Weiming Li, Qinghua ZhangAbstractIn recent years, microRNAs (miRNAs) have been shown to play important roles in immunity. Analyses of the functions of miRNAs and their targets are useful in understanding the regulation of the immune response. To understand the relationships between miRNAs and their targets during infection, we used zebrafish as an infection model in which to characterize the miRNA and mRNA transcriptomes of zebrafish larvae infected with Vibrio parahaemolyticus. We identifi...
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
This study indicates that dietary β-glucan supplement at 0.02%–0.04% can significantly improve digestibility, antioxidant capacity and immunity in L. vannamei, and thus improve growth performance and survival at low salinity. These beneficial effects of β-glucan probably are related to the dominance of probiotics over potential pathogens in the intestine.
Source: Fish and Shellfish Immunology - Category: Biology Source Type: research
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