Mechanical Stresses Induce Paracrine Beta-2 Microglobulin from Cardiomyocytes to Activate Cardiac Fibroblasts through Epidermal Growth Factor Receptor

This study suggests β2M is a paracrine pro-fibrotic mediator and associated with cardiac dysfunction in response to pressure overload.

Source: Clinical Science - August 2, 2018 Category: Biomedical Science Authors: Li, Y., Zhang, X., Li, L., Wang, X., Chen, Z., Wang, X., Wang, Y., Kang, L., Ye, Y., Jia, J., Zhang, G., Yang, C., Yuan, J., Zhou, J., Ge, J., Gong, H., Zou, Y. Tags: PublishAheadOfPrint Source Type: research